MR-PET für die Medizinische Bildgebung

用于医学成像的 MR-PET

• 批准号: 164562811
• 负责人: Professor Dr. Osama Sabri
• 金额: --
• 依托单位: Abteilung für Diagnostische und Interventionelle Radiologie
• 依托单位国家: 德国
• 项目类别: Major Instrumentation Initiatives
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/164562811?language=en
• 关键词: MR; PET; die; Medizinische; Bildgebung

In response to the DFG call for a PET-MR scanning system, the “Leipzig Combined PET-MRI” (LEipzig X combined PET-MRT, LEXPERT) initiative seeks funding. LEXPERT assembles an interdisciplinary consortium of internationally renowned PET and MRI imaging researchers from the Depts. of Nuclear Medicine (NUK), Diagnostic and Interventional Radiology (RAD), Neuroradiology (NEU), Pediatric Radiology (PED), and Cognitive Neurology at the University Hospital Leipzig, the Dept. of Neurology at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI), the Dept. of Diagnostic and Interventional Radiology at the University Leipzig / Heart Center Leipzig (HZL), and the Fraunhofer Institute for Cell Therapy and Immu-nology Leipzig (IZI). As such, we can draw from a broad PET and MR imaging expertise to ad-dress a wide spectrum of research topics ranging from preclinical animal models to clinical ap-plications in immunology, neurosurgery, pediatrics, neuropsychiatry, oncology and cardiology. For many research questions, combining functional and morphological imaging information as obtained by sequential PET, fMRI and/or MRI has already been established as a standard procedure since sufficient precision of coregistration can be obtained with software-based co-registration algorithms. However, when a finding in one imaging modality (e.g. PET) must be directly related to a certain (e.g. functional) state as defined by the other modality (e.g. fMRI), simultaneous PET-MR imaging becomes crucial. Therefore, we and others believe in the unique potential of combined PET-MRI to substantially advance the medical imaging repertoire avail-able for basic and clinical research. LEXPERT will focus on those scientific questions, for which simultaneous acquisition of the respective imaging data is key to improve diagnostics. Brain studies to be performed with the new combined imaging technique comprise basic re-search applications aiming at (i) establishing a “multimodal brain state neuroimaging“ with simul-taneous EEG, fMRI, and PET measurements and (ii) quantitative validation of BOLD fMRI con-trast by comparative perfusion PET. Preclinical large animal and clinical testing is planned for (iii) measuring the neurotransmitter / brain state effects of nicotine on addiction and dementia, (iv) investigating mood-affecting hormonal changes on serotonergic and general brain function, (v) verifying the stroke-MR concept currently in clinical routine in acute stage, (vi) improving the understanding, imaging and treatment of the ischemic penumbra in acute stroke, (vii) simulta-neously tracing stem cells and monitoring their treatment effects in stroke, as well as for (viii) simultaneously assessing cerebral metabolism and circulation in aneurysmal subarachnoid hemorrhage. In the area of tumor imaging, cervical cancer will be investigated as a model for the estab-lishment of combined whole-body PET-MRI to improve primary or recurrence tumor staging as well as therapy monitoring. This model was chosen to be the first in a simultaneous design based on the extreme challenge tumor-staging of cervical cancer poses in terms of spatial co-registration that is often limited in conventional sequential imaging design. We predict that pro-gress achieved for cervical cancer can then be transferred to other tumor entities. Further we aim to investigate the diagnostic potential of combined PET-MRI and the degree of anesthesia and radiation burden reduction for children suffering from Hodgkin’s disease, bone malignan-cies, and Ewing sarcoma (as compared to sequential whole-body PET-CT and MR imaging). In cardiac research, combined PET-MRI will be applied to (i) simultaneously image coronary artery morphology and inflammation to identify patients with vulnerable plaques at an early stage of disease, (ii) improve diagnosis of myocarditis, and to (iii) verify the concept of measur-ing myocardial perfusion versus the PET gold standard. The scientific expertise of LEXPERT is met with full commitment of the Leipzig University Hospital and the Medical Faculty of the Leipzig University to maximize the clinical impact of the PET-MR scanner in Leipzig. The first milestones of setting up the infrastructure required to in-stall a combined PET-MRI system have already been achieved. There is a clear financial com-mitment of the University Hospital Leipzig / Medical Faculty of the Leipzig University to cover follow-up expenditures, and additional funding will be secured from partners of the PET and MRI scanner, as well as image processing software and radiotracer manufacturing industry. To optimize the utilization of a combined PET-MRI system, a straight-forward user concept has been developed, which will allow access to “internal” and “external” scientists interested in this field and foster international collaboration. We are convinced that LEXPERT does not only meet all scientific and infrastructural prereq-uisites to successfully run a combined PET-MRI system, but that we have jointly developed a unique and ambitious research agenda to secure further cutting edge methodological develop-ment, solid scientific validation studies and clinical testing, and the exploration of compelling innovative applications of the simultaneous PET-MRI technique.

为了响应DFG对PET-MR扫描系统的呼吁，“莱比锡组合PET-MRI”（LEipzig X组合PET-MRT，LEXPERT）计划寻求资金。LEXPERT汇集了来自该部的国际知名PET和MRI成像研究人员的跨学科联盟。核医学（NUK），诊断和介入放射学（RAD），神经放射学（NEU），儿科放射学（PED）和认知神经学在莱比锡大学医院，该部门。马克斯·普朗克人类认知和脑科学研究所（MPI）神经学系。莱比锡大学诊断和介入放射学/莱比锡心脏中心（HZL）和莱比锡弗劳恩霍夫细胞治疗和免疫学研究所（IZI）。因此，我们可以利用广泛的PET和MR成像专业知识来解决广泛的研究课题，从临床前动物模型到免疫学、神经外科、儿科、神经精神病学、肿瘤学和心脏病学的临床应用。对于许多研究问题，结合功能和形态成像信息，通过连续PET，fMRI和/或MRI已经建立了一个标准的程序，因为足够的精度的配准可以获得基于软件的配准算法。然而，当一种成像模式（例如PET）中的发现必须与另一种模式（例如fMRI）定义的某种（例如功能）状态直接相关时，同步PET-MR成像变得至关重要。因此，我们和其他人相信，PET-MRI组合具有独特的潜力，可以大大提高基础和临床研究的医学成像水平。LEXPERT将专注于这些科学问题，同时采集相应的成像数据是改善诊断的关键。新的组合成像技术进行脑研究包括基本的研究应用，旨在（i）建立一个“多模态脑状态神经成像”与EEG，fMRI，PET同时测量和（ii）定量验证BOLD fMRI对比比较灌注PET。临床前大型动物和临床试验计划用于（iii）测量尼古丁对成瘾和痴呆的神经递质/脑状态影响，（iv）研究影响情绪的激素变化对尼古丁能和一般脑功能的影响，（v）验证急性期临床常规中的卒中-MR概念，（vi）改善急性卒中中缺血半暗带的理解、成像和治疗，（vii）同时追踪干细胞并监测其在中风中的治疗效果，以及（viii）同时评估蛛网膜下腔出血中的脑代谢和循环。在肿瘤成像领域，将研究宫颈癌作为建立联合全身PET-MRI的模型，以改善原发或复发肿瘤分期以及治疗监测。该模型被选为同时设计中的第一个，该设计基于宫颈癌在空间配准方面的极端挑战性肿瘤分期，而空间配准在传统的序贯成像设计中通常是有限的。我们预测，宫颈癌取得的进展可以转移到其他肿瘤实体。此外，我们的目的是研究联合PET-MRI的诊断潜力和麻醉程度，以及对儿童霍奇金病，骨恶性肿瘤和尤文肉瘤的放射负荷减少（与连续全身PET-CT和MR成像相比）。在心脏研究中，组合PET-MRI将用于（i）同时对冠状动脉形态和炎症进行成像，以在疾病的早期阶段识别具有易损斑块的患者，（ii）改善心肌炎的诊断，以及（iii）验证测量心肌灌注与PET金标准的概念。 莱比锡大学医院和莱比锡大学医学院全力支持LEXPERT的科学专业知识，以最大限度地发挥PET-MR扫描仪在莱比锡的临床影响。已经实现了建立安装组合PET-MRI系统所需的基础设施的第一个里程碑。莱比锡大学医院/莱比锡大学医学院明确承诺支付后续支出，并将从PET和MRI扫描仪以及图像处理软件和放射性示踪剂制造业的合作伙伴处获得额外资金。为了优化组合PET-MRI系统的利用，已经开发了一种直接的用户概念，这将允许访问对该领域感兴趣的“内部”和“外部”科学家，并促进国际合作。我们相信，LEXPERT不仅满足成功运行组合PET-MRI系统的所有科学和基础设施先决条件，而且我们还共同开发了一个独特而雄心勃勃的研究议程，以确保进一步的尖端方法开发，可靠的科学验证研究和临床测试，以及探索同步PET-MRI技术的引人注目的创新应用。