Correlation of Helicobacter pylori infection with gastroduodenal diseases in Nigeria - improvement of diagnosis and treatment

尼日利亚幽门螺杆菌感染与胃十二指肠疾病的相关性-诊断和治疗的改进

• 批准号: 164877145
• 负责人: Professor Dr. Rainer Haas
• 金额: --
• 依托单位: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/164877145?language=en
• 关键词: Correlation; Helicobacter; pylori; infection; gastroduodenal

Helicobacter pylori infections are frequent in developing countries and up to 85% of the population of Nigeria is affected. These Gram-negative bacteria are the causative agent of gastritis, peptic ulcer and represent a risk factor for the development of gastric cancers. H. pylori is fastidious to cultivate as well as diagnosis and treatment of this pathogen is difficult, especially in African countries. We managed to establish a local network consisting of four major hospitals located in different areas of Nigeria with a coordination centre in Lagos. H. pylori strains as well as biopsy material will be collected to study the epidemiological situation. Our study is aimed to implement more efficient methods for proper diagnosis and to improve treatment strategies against H. pylori, including novel and fast methods for H. pylori antibiotic resistance determination. In addition, the virulence potential of H. pylori strains in Nigeria will be determined and compared with diagnosed gastroduodenal disease. This is the first comprehensive study of its kind in Nigeria. The expected benefits include a perspective for Nigeria to build up and improve the infrastructure and the management of H. pylori-induced diseases. Our proposal integrates scientists from both Nigeria and Germany establishing a German-African network including an intense education program for Ph.D. students from Nigeria. This will result in a better career perspective for young scientists in Africa.

幽门螺杆菌感染在发展中国家很常见，尼日利亚高达85%的人口受到影响。这些革兰氏阴性细菌是胃炎、消化性溃疡的病原体，也是胃癌发生的危险因素。H.幽门螺杆菌的培养是很难的，而且这种病原体的诊断和治疗也很困难，特别是在非洲国家。我们设法建立了一个由位于尼日利亚不同地区的四家主要医院组成的地方网络，并在拉各斯设有一个协调中心。H.并会收集幽门螺杆菌菌株及活组织样本，以研究流行病学情况。我们的研究旨在实施更有效的方法，正确的诊断和改善治疗策略，对H。pylori，包括新的和快速的方法。幽门螺杆菌抗生素耐药性测定。此外，H.将确定尼日利亚的幽门螺杆菌菌株，并与诊断的胃十二指肠疾病进行比较。这是在尼日利亚进行的第一次此类综合研究。预期收益包括尼日利亚建立和改善H.幽门螺杆菌引起的疾病我们的建议整合了来自尼日利亚和德国的科学家，建立了一个德非网络，包括一个密集的博士教育计划。来自尼日利亚的学生。这将为非洲的年轻科学家带来更好的职业前景。