Purchase of a MALDI-TOF Mass Spectrometer

在化学研究仪器和设施（CRIF）计划的支持下，南加州大学化学系将获得一台基质辅助激光解吸电离-飞行时间（MALDI-TOF）质谱仪。该仪器将用于各种各样的研究项目，包括以下研究：a）小分子疗法中的结构-功能关系; B）用于光捕获和信息技术应用的新型大分子的合成; c）大环和嵌段共聚物的合成; d）用于可充电锂离子电池的聚合物电解质; d）包装RNA的结构、动力学和功能;和e）硅基单体和聚合物的分析。基质辅助激光解吸电离（MALDI）飞行时间（TOF）质谱是获得高达和超过300，000道尔顿的分子的精确分子量的首选技术，具有极高的灵敏度。因此，MALDI-TOF质谱仪的使用已成为标准技术，特别是在涉及生物分子的研究中。 这项研究将在许多领域产生重大影响，特别是聚合物研究和药物化学

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Southern California will acquire a Matrix-assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) Mass Spectrometer. This instrument will be used in a wide variety of research projects, including studies on a) the structure-function relationships in small molecule therapeutics; b) synthesis of novel macromolecules for light-harvesting and information technology applications; c) synthesis of macrocyclic and block copolymers; d) polymer electrolytes for rechargeable lithium ion batteries; d) structure, dynamics, and functions of packaging RNA; and e) analysis of silicon-based monomers and polymers. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially polymer studies and medicinal chemistry