CAREER: Development of a New Class Of Static and Dynamic Stereoselective Sensors

乔治城大学化学系的Christian Wolf教授获得了有机和大分子化学项目的支持，他的研究是开发具有C2对称1，8-二杂芳基萘框架的分子传感器，用于有机化合物的立体选择性识别。他将在立体选择性传感研究中制备和使用立体动力学的1，8-二喹啉基萘和构象稳定的1，8-二吖啶基萘，并研究手性识别机制。在追求利用荧光或诱导圆二色性的静态和动态传感器的新方向时，本研究有望显著推进精细化学品立体选择性传感的当前范围。在化学部有机和大分子化学计划的支持下，沃尔夫博士正在通过整合发现和研究，增加本科生和研究生对化学科学的参与和参与。学习由博士指导的选定研究项目学生为本科生提供实践研究经验，而研究生获得重要的团队合作和培训技能。将计算机为基础的学习练习和研究活动引入本科实验室课程，使学生在职业生涯的早期阶段就能感受到发现的兴奋。研究生一级的一项新举措旨在帮助博士生。学生在毕业前确定化学科学的就业机会。

Professor Christian Wolf of the Department of Chemistry at Georgetown University is supported by the Organic and Macromolecular Chemistry Program for his research on developing molecular sensors exhibiting a C2-symmetric 1,8-dihetarylnaphthalene framework for stereoselective recognition of organic compounds. He will prepare and employ stereodynamic 1,8-diquinolylnaphthalenes and conformationally stable 1,8-diacridylnaphthalenes in stereoselective sensing studies and investigate the chiral recognition mechanism. In pursuing new directions toward static and dynamic sensors that utilize fluorescence or induced circular dichroism, this study is expected to significantly advance the current scope of stereoselective sensing of fine chemicals.With the support of the Organic and Macromolecular Chemistry Program in the Chemistry Division, Dr Wolf is increasing participation and involvement of undergraduate and graduate students in chemical sciences through the integration of discovery and learning. Selected research projects mentored by Ph.D. students provide undergraduate students with hands-on research experience while graduate students gain important teamwork and training skills. The introduction of computer-based learning exercises and research activities into an undergraduate laboratory course is exposing students to the excitement of discovery at an early stage in their careers. A new initiative at the graduate level is aimed at helping Ph.D. students in identifying career opportunities in chemical sciences prior to graduation.