CAREER: Development of New Plasmonic Electrochemical Microscopy Centered Techniques for Advancing Single Entity Analysis

职业：开发以等离子体电化学显微镜为中心的新型技术，以推进单一实体分析

• 批准号: 2045839
• 负责人: Yixian Wang
• 金额: $ 47.5万
• 依托单位: California State L A University Auxiliary Services Inc.
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2045839&HistoricalAwards=false
• 关键词: CAREER; Development; New; Plasmonic; Electrochemical

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Dr. Yixian Wang and her group at California State University, Los Angeles are developing new techniques to study the chemistry of single nanoparticles, cells, cellular components, and molecules. The ability to investigate the chemistry of these single entities is significant because many complex systems consist of assemblies of individual parts that are not all alike. Understanding the function or behavior of the entire system often requires knowing how the individual components work. For example, it is important to know how a single leaf works in order to understand how a tree grows. Dr. Wang’s new techniques address key challenges faced by researchers studying the chemistry of nanoscopic particles using a specialized kind of microscopy. The new techniques overcome problems caused by contamination and other issues related to sample preparation, difficulty measuring especially small entities, and poor sensitivity in measuring some chemical reactions. In addition to cutting-edge research, the integrated educational activities of this work help to improve the quality and accessibility of STEM learning through the development of a new animation-based teaching module for undergraduate courses, as well as the integration of independent research projects into the undergraduate curriculum, and by engaging students from the local community through one-on-one research mentoring and virtual learning opportunities.Single entity analysis is essential for understanding the fundamental dynamics of real-world systems that are often heterogeneous. Dr. Yixian Wang and her group are developing three new plasmonic electrochemical microscopy (PEM)-centered techniques to improve the feasibility, resolution, and sensitivity of PEM for single entity analysis and to advance scientific progress in this field. Specifically, the research team is developing (1) non-contact PEM for background-free single nanoparticle measurements and contamination-free single vesicle sensing, (2) scanning probe coupled PEM to allow both high temporal and spatial resolution sub-nanoparticle analysis, and (3) dye-sensitized PEM to improve sensitivity in the chemical identification of single vesicle contents. The integrated educational activities of the project are designed to close learning gaps in undergraduate electrochemistry education, broaden student participation in STEM research, eliminate achievement gaps among diverse groups of students, and engage students from the local community in STEM-related activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学测量和成像计划的支持下，Yixian Wang博士和她在加利福尼亚州立大学的小组正在开发新技术，以研究单纳米颗粒，细胞，细胞，细胞成分和分子的化学性质。研究这些单一实体的化学性能的能力很重要，因为许多复杂的系统都由并非全部相似的各个部分组成。了解整个系统的功能或行为通常需要知道单个组件的工作方式。例如，重要的是要了解单叶如何工作，以了解树的生长方式。 Wang博士的新技术解决了研究人员使用专门的显微镜研究纳米粒子化学的关键挑战。新技术克服了由污染和与样品制备有关的其他问题引起的问题，在测量某些化学反应时，尤其是小型实体的困难以及敏感性不佳。除了尖端的研究外，这项工作的综合教育活动有助于通过开发新的基于动画的教学模块来提高STEM学习的质量和可访问性，并将独立的研究项目集成到本科课程中，并通过对当地社区的构建机构进行挑战，从而使学生从当地社区中互动，以使其成为现实的学习机会。通常是异质的。 Yixian Wang博士和她的小组正在开发三种新的塑料电化学显微镜（PEM）以中学的技术来提高PEM对单个实体分析的可行性，分辨率和敏感性，并提高该领域的科学进步。具体而言，研究团队正在开发（1）无接触式PEM，用于无背景的单纳米颗粒测量和无污染的单蔬菜敏感性，（2）扫描探针耦合PEM允许高临时和空间分辨率的临时和空间分辨率亚纳米颗粒分析，以及（3）在化学蔬菜中提高dye敏感的PEM，以提高dye敏感的PEM。 The integrated educational activities of the project are designed to close learning gaps in undergraduate electrochemistry education, broaden student participation in STEM research, eliminate achievement gaps among divers groups of students, and engage students from the local community in STEM-related activities.This award reflects NSF's statutory mission and has been deemed precious of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.