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Chemical and Biological Assessment of Endocrine Disruptors in Waterways of Southeast Texas

德克萨斯州东南部水道内分泌干扰物的化学和生物评估

基本信息

批准号：
0401587
负责人：
Bobby Wilson
金额：
$ 99.83万
依托单位：
Texas Southern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2004
资助国家：
美国
起止时间：
2004-05-01 至 2009-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0401587&HistoricalAwards=false
关键词：
Chemical Biological Assessment Endocrine Disruptors

项目摘要

HRD- 0401587Chemical and Biological Assessment of Endocrine Disruptors in Waterways in Southeast TexasTexas Southern UniversityPI: Joseph JonesGenetics and molecular biology researchers from Texas Southern University's Environmental Toxicology program will assess environmental contamination in the waterways of southeast Texas. Research will focus on chemical and biological endocrine disruptors in the lower Galveston Bay watershed. Research efforts will: (1) identify and quantify endocrine disruptors; (2) measure the effects of endocrine disruptors on cell proliferation and DNA repair in estrogen-sensitive cell lines; and (3) evaluate changes in dopamine content in neuronal cells treated with endocrine disruptors, and further examine the mechanism by which these chemicals may disrupt dopamine content.The project supports for a cadre of incoming doctoral students; faculty and graduate student participation at professional meetings; and, undergraduate and high school student supervised research opportunities managed through a Summer Internship Program. A regional conference on the multidisciplinary assessment of environmental contamination in Texas waterways will be held project-year 3.This project combines state of the art monitoring capabilities with cutting-edge basic research to define the biological sequel of exposure to identified aquatic endocrine disruptors. The work, to be conducted by Texas Southern University researchers, will incorporate underrepresented minority students at the high school, undergraduate, and graduate levels. Broader impacts of the proposed activity include the enhancement of the doctoral training capacity of TSU, and an increase in the number of underrepresented minority students entering into STEM-related graduate fields.

HRD-0401587德克萨斯州东南部水道内分泌干扰物的化学和生物评估德克萨斯州南方大学PI：约瑟夫琼斯来自德克萨斯州南方大学环境毒理学项目的遗传学和分子生物学研究人员将评估德克萨斯州东南部水道的环境污染。研究将集中在下加尔维斯顿湾流域的化学和生物内分泌干扰物。研究工作将：（1）确定和量化内分泌干扰物;（2）测量内分泌干扰物对雌激素敏感细胞系的细胞增殖和DNA修复的影响;（3）评估用内分泌干扰物处理的神经元细胞中多巴胺含量的变化，并进一步研究这些化学物质可能破坏多巴胺含量的机制。教师和研究生参与专业会议;和，本科生和高中生监督通过暑期实习计划管理的研究机会。项目第3年将举行一次关于德克萨斯州水道环境污染多学科评估的区域会议。该项目将最先进的监测能力与尖端的基础研究相结合，以确定暴露于已确定的水生内分泌干扰物的生物后果。这项工作将由得克萨斯南方大学的研究人员进行，将在高中、本科和研究生阶段纳入代表性不足的少数民族学生。拟议活动的更广泛影响包括加强大津国立大学的博士生培训能力，以及增加进入STEM相关研究生领域的代表性不足的少数民族学生人数。