Chiral Magic-Number Clusters & Non-Covalent Complexes Studied by Electrospray Ionization & Ion Soft Landing

手性幻数簇

• 批准号: 0412782
• 负责人: Robert Cooks
• 金额: $ 79.1万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0412782&HistoricalAwards=false
• 关键词: Chiral; Magic; Number; Clusters; &amp

Professor R. Graham Cooks of Purdue University is supported by the Analytical and Surface Chemistry Program to use the soft ionization capabilities of electrosonic spray ionization to generate molecular clusters probed by mass spectrometry. Reactions of these clusters will be carried out at atmospheric pressure prior to introduction of the products into a mass analyzer. Clusters and products are 'soft landed' onto surfaces (liquids and solids) after mass selection and detected using infrared laser desorption. The work focuses on the homochiral clusters of the amino acid serine discovered in the PI's laboratory, and on issues of chiral amplification and transfer of chirality to other species through enantioselective chemical reactions. Noncovalent bonding is an important topic in understanding interactions between biologically active molecules, as well as in many other areas including colloid chemistry and sensors. Thus, in addition to providing excellent student education, the PI continues to develop mass spectrometry ultimately for biology and security applications, for example.

普渡大学的R. Graham Cooks教授在分析和表面化学项目的支持下，利用电子声波喷雾电离的软电离能力，产生通过质谱探测的分子簇。在将产品引入质量分析仪之前，将在常压下进行这些簇的反应。团簇和产品在大量选择后“软着陆”在表面（液体和固体）上，并使用红外激光解吸进行检测。这项工作的重点是在PI实验室发现的氨基酸丝氨酸的同手性簇，以及通过对映选择性化学反应将手性扩增和转移到其他物种的问题。非共价键是理解生物活性分子之间相互作用的一个重要课题，在胶体化学和传感器等许多其他领域也是如此。因此，除了提供优秀的学生教育外，PI还将继续开发质谱法，最终用于生物和安全应用。