Ionic reactions in droplets and thin films for preparative and analytical mass spectrometry

在化学系化学测量和成像计划的支持下，普渡大学的Graham Cooks教授和他的团队将在开放的实验室环境中研究有机离子的反应及其产物的收集。化学的技术应用既依赖于化学反应，也依赖于化学分析。典型的化学反应包括制造药物、改进塑料和分解生物质以获得新燃料的反应。典型的化学分析包括监测血液中特定药物的水平，测量河流中的污染物，以及识别参议院办公室大楼信封中白色粉末的性质。质谱学是应用最广泛、灵敏度最高的化学分析方法之一。这项建议涉及尝试使用质谱学方法来提高化学反应的速度，以便快速制造少量的相关材料--即建立化合物库。这些化学物质可用于评估对某些酶或其他目的有反应的可能的生物活性化合物。放大质谱仪中发生的化学物质有可能通过新的途径产生新型化合物，例如通过空气中的电放电将氮固定(结合)到蜡(烷烃)中。该项目的更广泛影响将是在新仪器的设计和制造方面的教育。化学仪器是科学技术的核心能力之一，而仪器制造经验将成为影响该项目研究生和本科生职业生涯的一项技能。已经生产出新型仪器并导致商业化的原型开发工作将继续下去。每年为大约100人举办一次关于化学仪器的短期课程，将提高这方面的技能。该项目的研究成果将成为在有机和分析教学实验室开展实验的基础，有助于更有效地教授有机反应性。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Graham Cooks at Purdue University and his group will be studying the reactions of organic ions and the collection of their products in the open laboratory environment. Technological applications of chemistry depend upon both chemical reactions and on chemical analysis. Typical chemical reactions include those involved in making drugs, improving plastics, and breaking down biomass for new fuels. Typical chemical analyses include monitoring levels of specific drugs in blood, measuring pollutants in our rivers, and identifying the nature of white powders that are at the Senate Office building in envelopes. Mass spectrometry is one of the most widely used and sensitive methods of chemical analysis. This proposal involves attempts to use mass spectrometric methods to increase the rates of chemical reactions so as to make small quantities of sets of related materials quickly - that is to make libraries of compounds. These chemicals can be used for evaluating possible biologically active compounds that respond to certain enzymes or other purposes. Scaling up the chemistry that occurs in the mass spectrometer has the potential to generate new types of compounds by new routes, an example being fixing (incorporating) nitrogen into waxes (alkanes) by electrical discharges in air. Broader impacts of this project will be in education in the design and fabrication of new instrumentation. Chemical instrumentation is one of the core capabilities in science and technology and experience in building instrumentation will be a skill that will have impact over the careers of the graduate students and undergraduates involved in this project. Prototyping efforts that has produced new types of instruments and led to commercialization will be continued. An annual short course on chemical instrumentation for about 100 people will enhance skills in this area. Research results from the project will form the basis for developing experiments in organic and analytical teaching laboratories, helping to more effectively teach organic reactivity.