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Ion Reaction, Ion Dissociation and Ion Collection in the Open Laboratory Environment

开放实验室环境中的离子反应、离子解离和离子收集

基本信息

批准号：
0848650
负责人：
Robert Cooks
金额：
$ 95万
依托单位：
Purdue University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848650&HistoricalAwards=false
关键词：
Ion Reaction Dissociation Collection Open

项目摘要

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program supports Professor R. Graham Cooks of Purdue University to devise means of performing significant parts of the mass spectrometric experiment outside the mass spectrometer, in the open laboratory environment. In this way, it is hoped to achieve gains in speed and performance, while minimizing the inefficiencies associated with transferring ions into vacuum. Working with ions in the ambient environment also enables fuller exploration of the fundamental chemical relationships between the reactions of ions in solution and those of ions in the mass spectrometer. These studies gain broad impact because mass spectrometry is an analytical tool used widely in science and industry for chemical analysis; it has special roles in pharmaceutical discovery, environmental monitoring, food safety, forensics and biomedical research. Its high sensitivity, chemical specificity (low false positives), and the diversity of applications have elevated it to an outstanding position among methods of chemical analysis. Work in the Cooks laboratory also addresses the urgent national need to improve the infrastructure of science by contributing to the training of instrumentation scientists. Efforts are directed especially towards attracting women and minorities into this area.

该奖项由2009年美国复苏和再投资法案(公法111-5)资助。分析和表面化学计划支持普渡大学的R.Graham Cooks教授设计方法，在开放的实验室环境中，在质谱计之外执行重要的质谱学实验。通过这种方式，它有望实现速度和性能的提高，同时最大限度地减少将离子转移到真空中所带来的低效。在周围环境中处理离子还可以更全面地探索溶液中离子的反应和质谱仪中离子的反应之间的基本化学关系。这些研究获得了广泛的影响，因为质谱学是一种广泛应用于科学和工业中的化学分析工具；它在药物发现、环境监测、食品安全、法医学和生物医学研究中具有特殊的作用。它的高灵敏度、化学特异度(低假阳性)和应用的多样性使其在化学分析方法中处于突出地位。库克斯实验室的工作还解决了国家迫切需要改善科学基础设施的问题，为仪器科学家的培训做出了贡献。特别是努力吸引妇女和少数群体进入这一领域。