Ion Reaction, Ion Dissociation and Ion Collection in the Open Laboratory Environment

开放实验室环境中的离子反应、离子解离和离子收集

• 批准号: 0848650
• 负责人: Robert Cooks
• 金额: $ 95万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848650&HistoricalAwards=false
• 关键词: Ion; Reaction; Dissociation; Collection; Open

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program supports Professor R. Graham Cooks of Purdue University to devise means of performing significant parts of the mass spectrometric experiment outside the mass spectrometer, in the open laboratory environment. In this way, it is hoped to achieve gains in speed and performance, while minimizing the inefficiencies associated with transferring ions into vacuum. Working with ions in the ambient environment also enables fuller exploration of the fundamental chemical relationships between the reactions of ions in solution and those of ions in the mass spectrometer. These studies gain broad impact because mass spectrometry is an analytical tool used widely in science and industry for chemical analysis; it has special roles in pharmaceutical discovery, environmental monitoring, food safety, forensics and biomedical research. Its high sensitivity, chemical specificity (low false positives), and the diversity of applications have elevated it to an outstanding position among methods of chemical analysis. Work in the Cooks laboratory also addresses the urgent national need to improve the infrastructure of science by contributing to the training of instrumentation scientists. Efforts are directed especially towards attracting women and minorities into this area.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。分析和表面化学项目支持普渡大学的 R. Graham Cooks 教授设计在质谱仪之外、开放实验室环境中执行质谱实验重要部分的方法。通过这种方式，希望能够提高速度和性能，同时最大限度地减少与将离子转移到真空中相关的低效率。使用周围环境中的离子还可以更全面地探索溶液中离子的反应与质谱仪中离子的反应之间的基本化学关系。这些研究产生了广泛的影响，因为质谱分析是科学和工业中广泛用于化学分析的分析工具。它在药物发现、环境监测、食品安全、法医学和生物医学研究中发挥着特殊作用。其高灵敏度、化学特异性（低假阳性）和应用的多样性使其在化学分析方法中处于突出地位。 库克实验室的工作还通过促进仪器科学家的培训来满足国家改善科学基础设施的迫切需求。我们特别致力于吸引妇女和少数族裔进入这一领域。