Ion Reaction, Ion Dissociation and Ion Collection in the Open Laboratory Environment

开放实验室环境中的离子反应、离子解离和离子收集

• 批准号: 0848650
• 负责人: Robert Cooks
• 金额: $ 95万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848650&HistoricalAwards=false
• 关键词: Ion; Reaction; Dissociation; Collection; Open

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program supports Professor R. Graham Cooks of Purdue University to devise means of performing significant parts of the mass spectrometric experiment outside the mass spectrometer, in the open laboratory environment. In this way, it is hoped to achieve gains in speed and performance, while minimizing the inefficiencies associated with transferring ions into vacuum. Working with ions in the ambient environment also enables fuller exploration of the fundamental chemical relationships between the reactions of ions in solution and those of ions in the mass spectrometer. These studies gain broad impact because mass spectrometry is an analytical tool used widely in science and industry for chemical analysis; it has special roles in pharmaceutical discovery, environmental monitoring, food safety, forensics and biomedical research. Its high sensitivity, chemical specificity (low false positives), and the diversity of applications have elevated it to an outstanding position among methods of chemical analysis. Work in the Cooks laboratory also addresses the urgent national need to improve the infrastructure of science by contributing to the training of instrumentation scientists. Efforts are directed especially towards attracting women and minorities into this area.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助。普渡大学的Graham Cooks设计了在开放的实验室环境中，在质谱仪之外进行质谱实验的重要部分的方法。通过这种方式，希望实现速度和性能的提高，同时最大限度地减少与将离子转移到真空中相关的低效率。与周围环境中的离子一起工作还使得能够更充分地探索溶液中的离子的反应与质谱仪中的离子的反应之间的基本化学关系。这些研究获得了广泛的影响，因为质谱是一种广泛用于科学和工业化学分析的分析工具;它在药物发现，环境监测，食品安全，法医学和生物医学研究中具有特殊的作用。它的高灵敏度，化学特异性（低假阳性）和应用的多样性使其在化学分析方法中处于突出地位。 在库克实验室的工作还解决了迫切的国家需要改善科学基础设施，通过促进仪器科学家的培训。特别努力吸引妇女和少数民族进入这一领域。