Purchase of a 500 MHz NMR for Research and Teaching

购买 500 MHz NMR 用于研究和教学

• 批准号: 0417731
• 负责人: Leigh Plesniak
• 金额: $ 61.73万
• 依托单位: University of San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0417731&HistoricalAwards=false
• 关键词: Purchase; 500; MHz; NMR; Research

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of San Diego will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the characterization of hunter-killer peptide structures in the presence of membrane mimics; b) elucidation of solution structures of modified nucleic acids and their complexes with DNA binding ligands; c) characterization of self-assembled structures governed by hydrogen bond selectivities; d) structural characterization of theophylline-binding RNA aptamers with altered selectivities; and e) synthesis and structural characterization of pyrrole-based ligands and their metal-binding complexes. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.

有了这项来自主要研究仪器（MRI）计划的奖项，圣地亚哥大学化学系将获得一台500 MHz NMR光谱仪。该设备将使研究人员能够进行以下研究：a）在膜模拟物存在下的猎人杀伤肽结构的表征; B）修饰核酸及其与DNA结合配体的复合物的溶液结构的阐明; c）由氢键选择性控制的自组装结构的表征; d）具有改变的选择性的茶碱结合RNA适体的结构表征;和e）吡咯基配体及其金属结合配合物的合成和结构表征。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机化学和生物化学产生影响。