Purchase of a 500 MHz NMR for Research and Teaching

圣地亚哥大学化学系将获得一台500 MHz核磁共振光谱仪，该奖项来自主要研究仪器（MRI）项目。该设备将使研究人员能够开展以下研究：a)在膜模拟物存在下的猎人-杀手肽结构的表征；b)修饰的核酸及其与DNA结合配体的复合物的溶液结构的阐明；C)由氢键选择性控制的自组装结构的表征；d)选择性改变的茶碱结合RNA适体的结构特征；e)吡咯基配体及其金属结合配合物的合成与结构表征。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of San Diego will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the characterization of hunter-killer peptide structures in the presence of membrane mimics; b) elucidation of solution structures of modified nucleic acids and their complexes with DNA binding ligands; c) characterization of self-assembled structures governed by hydrogen bond selectivities; d) structural characterization of theophylline-binding RNA aptamers with altered selectivities; and e) synthesis and structural characterization of pyrrole-based ligands and their metal-binding complexes. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.