Purchase of a 500 MHz NMR Spectrometer

这项来自化学研究仪器和设施计划的奖项将帮助科罗拉多大学博尔德分校的化学系获得一台500 MHz的核磁共振光谱仪。将支持的研究活动包括：(1)立体选择性合成方法和顺序反应方案的开发；(2)阿霉素介导的DNA交联的研究；(3)有机合成的立体选择性和催化不对称方法的开发；(4)DNA和RNA的合成和生物有机研究；(5)蛋白质的结构测定；(6)天然产物和复杂碳水化合物的全合成和生物有机研究。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物和催化等领域以及生物学中都是有用的。

This award from the Chemistry Research Instrumentation and Facilities Program will help the Department of Chemistry at the University of Colorado--Boulder acquire a 500 MHz NMR Spectrometer. The research activities to be supported include: (1) development of stereoselective synthetic methods and sequential reactions schemes; (2) investigations of adriamycin-mediated DNA cross-links; (3) the development of stereoselective and catalytic asymmetric methods for organic synthesis; (4) synthetic and bioorganic studies of DNA and RNA; (5) structure determination of proteins; (6) the total synthesis and bioorganic studies of natural products and complex carbohydrates. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers and catalysis, and in biology.