Atmospheric Oxygen Effects on Insect Body Size and Tracheal Function
大气中的氧气对昆虫体型和气管功能的影响
基本信息
- 批准号:0419704
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-06-01 至 2009-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It has been hypothesized that the giant insects of the late Paleozoic were made possible by high atmospheric oxygen levels, and that current insect body sizes are constrained by our atmospheric oxygen level of 21%. This research will test this hypothesis with a series of experiments that examine the effect of single- and multi-generation exposure to different atmospheric O2 levels on insect size, developmental rate, tracheal structure and function. Most of these experiments use fruitflies (Drosophila melanogaster), but one broad comparative study of the developmental plasticity of 16 insect species in response to variation in atmospheric O2 levels is included. The first goal of this research is to test whether D. melanogaster evolve different body sizes in response to variation in atmospheric O2 level (10, 20, 40% O2) in the lab. A second goal is to determine whether atmospheric O2 level can serve as a constraint on the evolution of large body size in D. melanogaster by selecting for large size in different O2 atmospheres. A third goal is to test for O2 delivery limitations, and potential compensatory responses of the respiratory system to variation in atmospheric oxygen level in fruitflies. Specifically these experiments will examine respiratory responses to rearing flies in 10, 20 and 40% O2 for one generation, multiple generations, or when selecting for large size. Atmospheric O2 effects on the capacity of the tracheal system to deliver oxygen will be measured morphologically with electron microscopy, and physiologically by measuring the lowest O2 level that permits normal metabolic rate. A fourth goal is to test three non-alternative hypotheses for why rearing O2 level affects individual fruitfly size: 1) The Direct O2 Limitation (DOL) Hypothesis that increasing O2 availability increases larval growth rates by increasing nutrient intake rates, 2) The O2 Cue (OC) Hypothesis, that increasing oxygen levels extend development rate by delaying the initiation of molting, and 3) The Cell Size (CS) hypothesis, that higher O2 levels increase fly size by increasing cell size at constant cell number. Finally, we will test for the generality of rearing O2 level on insect size and development rate. This comparative study of 16 species will also test whether O2 effects on these variables are influenced by insect size, developmental pattern, or habitat. This project involves a unique system in which we can quantify the degree of physiological constraint (O2 availability) on the evolution of major life history traits (body size, developmental rate), and thus will be of interest to a wide array of evolutionary biologists, physiologists and ecologists. In addition, the possible control of atmospheric O2 on insect size (and historical insect gigantism) is of substantial interest to many non-biologists including paleogeologists, environmental scientists and the general public. Results will be widely disseminated through reviewed scientific papers in physiological and evolutionary journals as well as more general outlets such as Scientific American or Natural History. A web site on insect respiratory physiology and oxygen effects on insect size will be created and linked to the Insect Physiology On-line web site (http://lamar.colostate.edu/%7Einsects/index.html). Finally, this award will also fund postdoctoral, graduate, and undergraduate training programs for individuals from groups currently under-represented among biology professions.
有人假设,古生代晚期的巨型昆虫是由于大气中的高含氧量而成为可能的,而目前的昆虫身体大小受到我们21%的大气含氧量的限制。 本研究将通过一系列实验来验证这一假设,这些实验将研究单代和多代暴露于不同大气O2水平对昆虫大小,发育速率,气管结构和功能的影响。 大多数这些实验使用果蝇(果蝇),但一个广泛的比较研究的16种昆虫的发育可塑性在大气中的O2水平的变化。 本研究的第一个目的是检验D.在实验室条件下,黑腹果蝇对不同浓度O2(10、20、40%O2)的反应是不同的。 第二个目标是确定大气中的O2水平是否可以作为一个约束的发展大型机构在D。黑腹果蝇在不同的O2气氛中选择大尺寸。 第三个目标是测试O2输送限制,以及呼吸系统对果蝇大气氧含量变化的潜在补偿反应。 具体而言,这些实验将检查呼吸反应饲养苍蝇在10,20和40%的O2为一代,多代,或当选择大尺寸。 大气O2对气管系统供氧能力的影响将通过电子显微镜在形态学上进行测量,并通过测量允许正常代谢率的最低O2水平在生理学上进行测量。 第四个目标是测试为什么饲养O2水平影响个体果蝇大小的三个非替代假设:1)直接O2限制(DOL)假说,即增加O2可用性通过增加营养摄入速率来增加幼虫生长速率,2)O2线索(OC)假说,即增加氧水平通过延迟蜕皮的开始来延长发育速率,3)细胞大小(CS)假说,即较高的O2水平通过在恒定的细胞数量下增加细胞大小来增加苍蝇大小。 最后,我们将测试饲养O2水平对昆虫大小和发育速度的通用性。 这项对16个物种的比较研究还将测试O2对这些变量的影响是否受到昆虫大小、发育模式或栖息地的影响。 该项目涉及一个独特的系统,在该系统中,我们可以量化生理约束(O2可用性)对主要生活史特征(体型,发育率)进化的程度,因此将引起广泛的进化生物学家,生理学家和生态学家的兴趣。 此外,大气O2对昆虫大小的可能控制(以及历史上的昆虫寄生)引起了许多非生物学家的极大兴趣,包括古地质学家,环境科学家和公众。 研究结果将通过生理学和进化学期刊上的综述性科学论文以及《科学美国人》或《自然历史》等更一般的媒体广泛传播。 将建立一个关于昆虫呼吸生理学和氧气对昆虫大小影响的网站,并将其与昆虫生理学在线网站(http://lamar.colostate.edu/%7Einsects/index.html)链接。 最后,该奖项还将资助博士后,研究生和本科生培训计划,为目前生物专业中代表性不足的群体提供个人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jon Harrison其他文献
903 SINGLE-CELL RNA SEQUENCING ANALYSIS OF PANCREATIC DUCTAL ADENOCARCINOMA REVEALS TRANSCRIPTOMIC CHANGES IN FIBROBLASTS FOLLOWING FOLFIRINOX-BASED NEOADJUVANT CHEMORADIATION THERAPY
- DOI:
10.1016/s0016-5085(21)02895-x - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Jon Harrison;Jonathan E. Chang;Michelle Piquet;Slavica Dimitrieva;Millicent Gabriel;Keith D. Lillemoe;Andrew L. Warshaw;Mari Mino-Kenudson;Carlos Férnandez-Del Castillo;Viviana Cremasco;Dave Ruddy;Andrew S. Liss - 通讯作者:
Andrew S. Liss
Periodic Orbits on 2-Regular Circulant Digraphs
- DOI:
10.1007/s00373-025-02931-8 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:0.600
- 作者:
Isaac Echols;Jon Harrison;Tori Hudgins - 通讯作者:
Tori Hudgins
797 SINGLE-CELL RNA SEQUENCING ANALYSIS OF PANCREATIC DUCTAL ADENOCARCINOMA REVEALS INTERTUMORAL TRANSCRIPTOMIC HETEROGENEITY
- DOI:
10.1016/s0016-5085(20)34498-x - 发表时间:
2020-05-01 - 期刊:
- 影响因子:
- 作者:
Jon Harrison;Jonathan E. Chang;Michelle Piquet;Slavica Dimitrieva;Millicent Gabriel;Thomas P. Hank;Keith Lillemoe;Andrew L. Warshaw;Mari Mino-Kenudson;Carlos Fernandez-del Castillo;Viviana Cremasco;Dave Ruddy;Andrew S. Liss - 通讯作者:
Andrew S. Liss
"Duct tape:" Management strategies for the pancreatic anastomosis during pancreatoduodenectomy.
“管道胶带:”胰十二指肠切除术期间胰腺吻合的管理策略。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:3.8
- 作者:
Jon Harrison;M. Dua;W. Kastrinakis;Peter J. Fagenholz;C. F. Fernandez;K. Lillemoe;G. Poultsides;B. Visser;M. Qadan - 通讯作者:
M. Qadan
Jon Harrison的其他文献
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{{ truncateString('Jon Harrison', 18)}}的其他基金
Meeting: SICB symposium for January 2022: Causal Mechanisms of Metabolic Scaling
会议:2022 年 1 月 SICB 研讨会:代谢缩放的因果机制
- 批准号:
2141592 - 财政年份:2021
- 资助金额:
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Collaborative Research: Brain Size, Metabolism, and Sociality in Ants
合作研究:蚂蚁的大脑大小、新陈代谢和社交性
- 批准号:
1953419 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Standard Grant
Breaking Boundaries for Evolutionary Synthesis: An Interactive and Integrative Symposium Linking Crustacean and Insect Physiology- West Palm Beach, Florida; January, 2015
打破进化综合的界限:连接甲壳类动物和昆虫生理学的互动综合研讨会 - 佛罗里达州西棕榈滩;
- 批准号:
1507854 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Is hypoxia a critical cue for molting in Drosphila?
合作研究:缺氧是果蝇蜕皮的关键线索吗?
- 批准号:
1256745 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Metabolic and behavioral integration in social insect colonies
论文研究:社会性昆虫群体的代谢和行为整合
- 批准号:
1110796 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Standard Grant
Structural and functional scaling of the respiratory system of flying beetles
飞甲虫呼吸系统的结构和功能缩放
- 批准号:
1122157 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Continuing Grant
International DDEP: Grasshopper migration in the Asian steppe: investigating diet as a cue for polyphenism
国际 DDEP:亚洲草原上的蚱蜢迁徙:调查饮食作为多型现象的线索
- 批准号:
1026182 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Standard Grant
Workshop: Variable Atmosphere Laboratory (VAL) Workshop 2; Arlington, VA; May 2009
研讨会:可变气氛实验室(VAL)研讨会2;
- 批准号:
0929344 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Standard Grant
Atmospheric Oxygen Influences on the Size of Modern and Fossil Insects.
大气中的氧气对现代昆虫和化石昆虫的大小的影响。
- 批准号:
0746352 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Continuing Grant
Workshop: Design and Scientific Merit of the Variable Atmosphere Laboratory (VAL), to be held on March 6 - 7, 2008 in Tempe, AZ.
研讨会:可变大气实验室 (VAL) 的设计和科学优点,将于 2008 年 3 月 6 日至 7 日在亚利桑那州坦佩举行。
- 批准号:
0748882 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Continuing Grant
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