Structural and functional scaling of the respiratory system of flying beetles
飞甲虫呼吸系统的结构和功能缩放
基本信息
- 批准号:1122157
- 负责人:
- 金额:$ 59.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
One obvious pattern in animal biology is that insects and other arthropods are generally smaller than vertebrates. Why is this? More than 300 million years ago, in the late Paleozoic, giant insects up to 10-fold larger than those alive today roamed the earth. Recent findings from geologists have shown that the atmosphere had substantially more oxygen than today (31% vs. 21% today). These findings suggest that insects are small today (and were giant in the Paleozoic) because of the way they delivery oxygen to their tissues. This project tests this hypothesis by using fruit chafer beetles, the largest beetles living in the world today. Physiological and imaging experiments will be conducted to determine whether larger insects invest a greater fraction of their body as respiratory structure, and experience associated negative consequences (or trade-offs) such as reduced proportional sizes of the brain or digestive tract. A newly developed neural stimulating system will be used to assess respiratory function during the high demands of flight. 3D x-ray tomography and confocal microscopy will be used to measure the volume and structure of the respiratory system, brain, digestive tract, and muscles. Using such technologies, this project will test whether larger beetles must reduce the size and function of essential organs (such as the brain) in order to deliver oxygen to their tissues ? the limited by oxygen delivery hypothesis. Thus, this project has the potential to explain one of the most broad-scale patterns in animal biology. Understanding such physical limits on animal design is critical for development of new technologies for engineering micro-injection systems that utilize bio-inspired fluidic systems, and for understanding the potential effects of atmospheric changes on animals. This research project will also include educational and training components, including development of a web-based K-12 teaching resource, and research training for graduate, undergraduate, and high school students.
动物生物学中一个明显的模式是昆虫和其他节肢动物通常比脊椎动物小。为什么会这样呢?3亿多年前,在晚古生代,比今天的昆虫大10倍的巨型昆虫在地球上漫游。地质学家最近的发现表明,大气中的氧气比今天多得多(31%比今天的21%)。这些发现表明,今天的昆虫很小(在古生代是巨大的),因为它们向组织输送氧气的方式。这个项目通过使用水果金龟子来验证这一假设,水果金龟子是当今世界上最大的甲虫。将进行生理学和成像实验,以确定较大的昆虫是否将其身体的更大部分作为呼吸结构,并经历相关的负面后果(或权衡),例如大脑或消化道的比例尺寸减小。一种新开发的神经刺激系统将用于评估飞行高要求期间的呼吸功能。3D X射线断层扫描和共聚焦显微镜将用于测量呼吸系统,大脑,消化道和肌肉的体积和结构。利用这些技术,该项目将测试大型甲虫是否必须减少重要器官(如大脑)的大小和功能,以向其组织输送氧气?氧气输送限制假说 因此,该项目有可能解释动物生物学中最广泛的模式之一。了解动物设计的这种物理限制对于开发利用生物启发流体系统的工程微注射系统的新技术以及了解大气变化对动物的潜在影响至关重要。该研究项目还将包括教育和培训部分,包括基于网络的K-12教学资源的开发,以及研究生,本科生和高中生的研究培训。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jon Harrison其他文献
903 SINGLE-CELL RNA SEQUENCING ANALYSIS OF PANCREATIC DUCTAL ADENOCARCINOMA REVEALS TRANSCRIPTOMIC CHANGES IN FIBROBLASTS FOLLOWING FOLFIRINOX-BASED NEOADJUVANT CHEMORADIATION THERAPY
- DOI:
10.1016/s0016-5085(21)02895-x - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Jon Harrison;Jonathan E. Chang;Michelle Piquet;Slavica Dimitrieva;Millicent Gabriel;Keith D. Lillemoe;Andrew L. Warshaw;Mari Mino-Kenudson;Carlos Férnandez-Del Castillo;Viviana Cremasco;Dave Ruddy;Andrew S. Liss - 通讯作者:
Andrew S. Liss
Periodic Orbits on 2-Regular Circulant Digraphs
- DOI:
10.1007/s00373-025-02931-8 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:0.600
- 作者:
Isaac Echols;Jon Harrison;Tori Hudgins - 通讯作者:
Tori Hudgins
797 SINGLE-CELL RNA SEQUENCING ANALYSIS OF PANCREATIC DUCTAL ADENOCARCINOMA REVEALS INTERTUMORAL TRANSCRIPTOMIC HETEROGENEITY
- DOI:
10.1016/s0016-5085(20)34498-x - 发表时间:
2020-05-01 - 期刊:
- 影响因子:
- 作者:
Jon Harrison;Jonathan E. Chang;Michelle Piquet;Slavica Dimitrieva;Millicent Gabriel;Thomas P. Hank;Keith Lillemoe;Andrew L. Warshaw;Mari Mino-Kenudson;Carlos Fernandez-del Castillo;Viviana Cremasco;Dave Ruddy;Andrew S. Liss - 通讯作者:
Andrew S. Liss
"Duct tape:" Management strategies for the pancreatic anastomosis during pancreatoduodenectomy.
“管道胶带:”胰十二指肠切除术期间胰腺吻合的管理策略。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:3.8
- 作者:
Jon Harrison;M. Dua;W. Kastrinakis;Peter J. Fagenholz;C. F. Fernandez;K. Lillemoe;G. Poultsides;B. Visser;M. Qadan - 通讯作者:
M. Qadan
Jon Harrison的其他文献
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{{ truncateString('Jon Harrison', 18)}}的其他基金
Meeting: SICB symposium for January 2022: Causal Mechanisms of Metabolic Scaling
会议:2022 年 1 月 SICB 研讨会:代谢缩放的因果机制
- 批准号:
2141592 - 财政年份:2021
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
Collaborative Research: Brain Size, Metabolism, and Sociality in Ants
合作研究:蚂蚁的大脑大小、新陈代谢和社交性
- 批准号:
1953419 - 财政年份:2020
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
Breaking Boundaries for Evolutionary Synthesis: An Interactive and Integrative Symposium Linking Crustacean and Insect Physiology- West Palm Beach, Florida; January, 2015
打破进化综合的界限:连接甲壳类动物和昆虫生理学的互动综合研讨会 - 佛罗里达州西棕榈滩;
- 批准号:
1507854 - 财政年份:2015
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
Collaborative Research: Is hypoxia a critical cue for molting in Drosphila?
合作研究:缺氧是果蝇蜕皮的关键线索吗?
- 批准号:
1256745 - 财政年份:2013
- 资助金额:
$ 59.42万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Metabolic and behavioral integration in social insect colonies
论文研究:社会性昆虫群体的代谢和行为整合
- 批准号:
1110796 - 财政年份:2011
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
International DDEP: Grasshopper migration in the Asian steppe: investigating diet as a cue for polyphenism
国际 DDEP:亚洲草原上的蚱蜢迁徙:调查饮食作为多型现象的线索
- 批准号:
1026182 - 财政年份:2010
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
Workshop: Variable Atmosphere Laboratory (VAL) Workshop 2; Arlington, VA; May 2009
研讨会:可变气氛实验室(VAL)研讨会2;
- 批准号:
0929344 - 财政年份:2009
- 资助金额:
$ 59.42万 - 项目类别:
Standard Grant
Atmospheric Oxygen Influences on the Size of Modern and Fossil Insects.
大气中的氧气对现代昆虫和化石昆虫的大小的影响。
- 批准号:
0746352 - 财政年份:2008
- 资助金额:
$ 59.42万 - 项目类别:
Continuing Grant
Workshop: Design and Scientific Merit of the Variable Atmosphere Laboratory (VAL), to be held on March 6 - 7, 2008 in Tempe, AZ.
研讨会:可变大气实验室 (VAL) 的设计和科学优点,将于 2008 年 3 月 6 日至 7 日在亚利桑那州坦佩举行。
- 批准号:
0748882 - 财政年份:2007
- 资助金额:
$ 59.42万 - 项目类别:
Continuing Grant
Atmospheric Oxygen Effects on Insect Body Size and Tracheal Function
大气中的氧气对昆虫体型和气管功能的影响
- 批准号:
0419704 - 财政年份:2004
- 资助金额:
$ 59.42万 - 项目类别:
Continuing Grant
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