MRI: Acquisition of a Preparative HPLC system for Undergraduate Research Training in Chemistry and Biology

科尔比学院化学系将获得重大研究仪器(MRI)计划颁发的这一奖项，从而获得制备型高效液相色谱(HPLC)系统。该设备将加强以下领域的研究：a)用于合成卡宾的前体的提纯；b)天然产物的合成；c)氮杂和氧杂杯芳烃大环和双杂杯芳烃笼状化合物的合成；c)小分子与DNA的相互作用的研究；d)双链DNA与小过渡金属化合物之间的共价相互作用的研究；以及e)青蛙皮肤分泌物的分析。高效液相色谱是一种用于分离和分析复杂混合物的极其强大的技术。这些研究的结果将对包括合成化学和生物化学在内的许多领域产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Colby College will acquire a preparative high performance liquid chromatography (HPLC) system. This equipment will enhance research in a number of areas including a) purification of precursors used to synthesize carbenes; b) synthesis of natural products; c) synthesis of aza- and oxocalixarene macrocycles and diheterocalixarene cage compounds; c) studies of the interactions of small molecules with DNA; d) investigations on the covalent interactions between duplex DNA and small transition metal compounds; and e) analysis of frog skin secretions. High performance liquid chromatography (HPLC) is an extremely powerful technique used for the separation and analysis of complex mixtures. The results from these studies will have an impact in a number of areas including synthetic chemistry and biochemistry.