MRI: Acquisition of a Preparative HPLC system for Undergraduate Research Training in Chemistry and Biology

MRI：为化学和生物学本科生研究培训购买制备型 HPLC 系统

• 批准号: 0421122
• 负责人: Dasan Thamattoor
• 金额: $ 12.87万
• 依托单位: Colby College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0421122&HistoricalAwards=false
• 关键词: MRI; Acquisition; Preparative; HPLC; system

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Colby College will acquire a preparative high performance liquid chromatography (HPLC) system. This equipment will enhance research in a number of areas including a) purification of precursors used to synthesize carbenes; b) synthesis of natural products; c) synthesis of aza- and oxocalixarene macrocycles and diheterocalixarene cage compounds; c) studies of the interactions of small molecules with DNA; d) investigations on the covalent interactions between duplex DNA and small transition metal compounds; and e) analysis of frog skin secretions. High performance liquid chromatography (HPLC) is an extremely powerful technique used for the separation and analysis of complex mixtures. The results from these studies will have an impact in a number of areas including synthetic chemistry and biochemistry.

从主要研究仪器（MRI）计划的这一奖项，化学系在科尔比学院将获得制备高效液相色谱（HPLC）系统。该设备将加强若干领域的研究，包括：a）用于合成卡宾的前体的纯化; B）天然产物的合成; c）氮杂和氧代杯芳烃大环和二杂杯芳烃笼状化合物的合成; c）小分子与DNA的相互作用的研究; d）双链DNA与小过渡金属化合物之间的共价相互作用的研究;和e）青蛙皮肤分泌物的分析。高效液相色谱（HPLC）是一种非常强大的技术，用于复杂混合物的分离和分析。这些研究的结果将对合成化学和生物化学等多个领域产生影响。