Acquisition of an Agilent 1100 Series MALDI/LC TOF Mass Spectrometer for Three Collaborating Departments at Duquesne University

为杜肯大学三个合作部门购买 Agilent 1100 系列 MALDI/LC TOF 质谱仪

• 批准号: 0421252
• 负责人: Howard Kingston
• 金额: --
• 依托单位: Duquesne University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0421252&HistoricalAwards=false
• 关键词: Acquisition; Agilent; 1100; Series; MALDI

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Duquesne University will acquire a Matrix-assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) Liquid-Chromatograph Mass Spectrometer. This instrument will be used in a wide variety of research projects, including studies on a) organic and inorganic synthesis reactions; b) correlating specific proteins with defined genetic activity; c) identifying and exploiting the bio-markers for discrete conditions or outcomes; and d) quantitative characterization of various types of surface modifications, from functionalized self assembled monolayers to fingerprints and genetic material. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially biochemistry, medicinal chemistry and materials science.

在主要研究仪器（MRI）计划的支持下，迪克讷大学化学和生物化学系将获得一台基质辅助激光解吸电离飞行时间（MALDI-TOF）液相色谱质谱仪。该仪器将用于各种各样的研究项目，包括以下方面的研究：a）有机和无机合成反应; B）将特定蛋白质与确定的遗传活性相关联; c）识别和利用离散条件或结果的生物标志物; d）从功能化自组装单分子层到指纹和遗传物质的各种类型表面修饰的定量表征。基质辅助激光解吸电离（MALDI）飞行时间（TOF）质谱是获得高达和超过300，000道尔顿的分子的精确分子量的首选技术，具有极高的灵敏度。因此，MALDI-TOF质谱仪的使用已成为标准技术，特别是在涉及生物分子的研究中。 这项研究将在许多领域产生重大影响，特别是生物化学，药物化学和材料科学。