US Austria-Denmark Cooperative Research: Modeling and Control of the Cardiovascular-Respiratory System

0437037Olufsen该奖项支持一个数学模型的开发，该模型预测立位应激和低血容量期间的短期心血管调节。即将推出的模型将包含三个子模型：预测心血管系统中的血压和流量的心血管模型，预测自主神经系统的交感神经和副交感神经活动的模型，以及预测二氧化碳和氧气浓度的模型。这些模型将通过自主监管和自动监管的模型进行组合。此外，将使用正式的统计和计算方法来估计模型中的参数，重点是说明和探索不同个人之间的变异性潜在机制。特别是，数学模型将根据已有的低血容量和立位压力测试数据进行验证，这些数据是在从坐到站、头朝上倾斜和下半身负压的姿势变化过程中获得的。这项研究项目是丹麦的J.Ottesen和奥地利的J.Batzel和F.Kappl合作完成的。过去，每个小组都在相关领域进行了成功的研究项目。随着美国和外国小组对这一项目的关注和专业知识，合作将在这一研究领域取得重大进展。为了加强抗高血压治疗，进一步了解衰老和高血压对脑循环的影响是必不可少的。由于最近的研究表明高血压与认知功能障碍的发展有关，了解高血压对脑血流灌注的影响是至关重要的。尽管这些临床问题很重要，但由于测量大脑自动调节的非侵入性方法不充分，以及对脑血管运动的假设检验不足，回答这些问题的进展一直受到阻碍。该奖项将支持旨在帮助检测和补救这些和其他潜在威胁生命的伤害或情况的研究。

0437037OlufsenThis award supports the development of a mathematical model predicting short-term cardiovascular regulation during orthostatic stress and hypovolemia. The model to be derived will contain three sub-models: A cardiovascular model predicting blood pressure and flow in the cardiovascular system, a model predicting sympathetic and parasympathetic activity of the autonomic nervous system, and a model predicting concentrations of carbon dioxide and oxygen. These models will be combined through models for autonomic regulation and autoregulation. In addition, formal statistical and computational methods will be used to estimate parameters in the models with emphasis on accounting for and exploring variability underlying mechanisms across different individuals. In particular, the mathematical model will be validated against already existing data from hypovolemia and orthostatic stress tests, obtained during postural change from sitting to standing, head up tilt, and lower body negative pressure.This research project is a collaborative effort between the PIs, J. Ottesen of Denmark, and J. Batzel and F. Kappel of Austria. In the past, each group has conducted successful research projects in related areas. With the attention and expertise of the US and foreign groups focused on this project, the collaboration will make significant progress in this area of research.In order to enhance antihypertensive therapy, further knowledge of the effects of aging and hypertension on the cerebral circulation is essential. Since recent studies show a relationship between hypertension and development of cognitive dysfunction, it is crucial to understand the effect of hypertension on cerebral perfusion. Despite the importance of these clinical questions, progress towards answering them has been impeded by inadequate non-invasive methods to measure cerebral autoregulation, and inadequately tested assumptions about cerebral vasomotion. This award will support research designed to aid in the detection and remediation of these and other potentially life threatening injuries or conditions.