US Austria-Denmark Cooperative Research: Modeling and Control of the Cardiovascular-Respiratory System

该奖项支持一种数学模型的开发，该模型可预测直立应激和低血容量时的短期心血管调节。该模型将包含三个子模型：预测心血管系统血压和血流的心血管模型，预测自主神经系统交感和副交感神经活动的模型，以及预测二氧化碳和氧气浓度的模型。这些模型将通过自主调节和自动调节模型相结合。此外，将使用正式的统计和计算方法来估计模型中的参数，重点是考虑和探索不同个体之间的变异性潜在机制。特别是，数学模型将根据现有的低血容量和直立性压力测试数据进行验证，这些数据是在坐姿转变为站立、头部向上倾斜和下体负压时获得的。这项研究项目是由PIs、丹麦的J. Ottesen和奥地利的J. Batzel和F. Kappel合作完成的。在过去，每个小组都在相关领域进行了成功的研究项目。随着美国和外国团体对该项目的关注和专业知识的集中，该合作将在这一研究领域取得重大进展。为了加强降压治疗，进一步了解衰老和高血压对脑循环的影响是必要的。由于近年来的研究表明高血压与认知功能障碍的发展之间存在关系，因此了解高血压对脑灌注的影响至关重要。尽管这些临床问题很重要，但由于测量大脑自动调节的非侵入性方法不足，以及关于脑血管舒缩的假设没有得到充分检验，这些问题的答案一直受到阻碍。该奖项将支持旨在帮助检测和补救这些和其他潜在威胁生命的伤害或条件的研究。

0437037OlufsenThis award supports the development of a mathematical model predicting short-term cardiovascular regulation during orthostatic stress and hypovolemia. The model to be derived will contain three sub-models: A cardiovascular model predicting blood pressure and flow in the cardiovascular system, a model predicting sympathetic and parasympathetic activity of the autonomic nervous system, and a model predicting concentrations of carbon dioxide and oxygen. These models will be combined through models for autonomic regulation and autoregulation. In addition, formal statistical and computational methods will be used to estimate parameters in the models with emphasis on accounting for and exploring variability underlying mechanisms across different individuals. In particular, the mathematical model will be validated against already existing data from hypovolemia and orthostatic stress tests, obtained during postural change from sitting to standing, head up tilt, and lower body negative pressure.This research project is a collaborative effort between the PIs, J. Ottesen of Denmark, and J. Batzel and F. Kappel of Austria. In the past, each group has conducted successful research projects in related areas. With the attention and expertise of the US and foreign groups focused on this project, the collaboration will make significant progress in this area of research.In order to enhance antihypertensive therapy, further knowledge of the effects of aging and hypertension on the cerebral circulation is essential. Since recent studies show a relationship between hypertension and development of cognitive dysfunction, it is crucial to understand the effect of hypertension on cerebral perfusion. Despite the importance of these clinical questions, progress towards answering them has been impeded by inadequate non-invasive methods to measure cerebral autoregulation, and inadequately tested assumptions about cerebral vasomotion. This award will support research designed to aid in the detection and remediation of these and other potentially life threatening injuries or conditions.