CAREER: From Biomimetic Reaction Platforms to Nanostructured Artificial Enzymes

无机、生物无机和有机金属化学项目的CAREER奖支持俄亥俄州迈阿密大学周洪才教授建立包含杂双金属反应中心的配位网络的工作。利用金属酶的结构/性质关系来指导多孔配位聚合物纳米通道内金属中心反应平台的构建，将为催化应用提供新的材料。在国家科学基金会的支持下，构建具有桨轮分子框架和纳米结构人工酶的仿生反应平台。纳米技术和生物无机反应之间的界面将是研究项目的核心，也是为本科生和研究生开设的新课程的核心。新学年课程的另一个成果将是一个夏季研讨会，讨论纳米技术和生物启发合成，该研讨会将向高中学生开放，由迈阿密大学的学生领导。天然酶的能力提供了复杂分子结构的例子，用于选择性地催化重要的生物反应。该项目将利用酶促反应中明显的概念来指导金属有机材料的合成，这些材料的性质类似于蛋白质中的反应中心。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Hongcai Zhou at Miami University in Ohio to build coordination networks containing heterobimetallic reaction centers. Using structure/property relationships of metalloenzymes to guide construction of metal-centered reaction-platforms inside of nanochannels in porous coordination polymers will provide new materials for use in catalysis. Biomimetic reaction platforms with paddlewheel molecular frameworks and nanostructured artificial enzymes will be constructed with support provided by NSF. The interface between nanotechnology and bioinorganic reactions will be central to both the research project and to a new course for undergraduate and graduate students. An additional outcome of the new academic year course will be a summer workshop addressing both nanotechnology and bioinspired synthesis, and the workship will be open to high school students and led by students from Miami University. The capabilities of natural enzymes provide examples of complex molecular structures designed to selectively catalyze important biological reactions. This project will use concepts evident in enzymatic reactions to guide the synthesis of metal-organic materials with properties resembling those of reaction centers in proteins.