CAREER: From Biomimetic Reaction Platforms to Nanostructured Artificial Enzymes

职业生涯：从仿生反应平台到纳米结构人工酶

• 批准号: 0449634
• 负责人: Hongcai Zhou
• 金额: $ 52.5万
• 依托单位: Miami University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0449634&HistoricalAwards=false
• 关键词: CAREER; Biomimetic; Reaction; Platforms; Nanostructured

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Hongcai Zhou at Miami University in Ohio to build coordination networks containing heterobimetallic reaction centers. Using structure/property relationships of metalloenzymes to guide construction of metal-centered reaction-platforms inside of nanochannels in porous coordination polymers will provide new materials for use in catalysis. Biomimetic reaction platforms with paddlewheel molecular frameworks and nanostructured artificial enzymes will be constructed with support provided by NSF. The interface between nanotechnology and bioinorganic reactions will be central to both the research project and to a new course for undergraduate and graduate students. An additional outcome of the new academic year course will be a summer workshop addressing both nanotechnology and bioinspired synthesis, and the workship will be open to high school students and led by students from Miami University. The capabilities of natural enzymes provide examples of complex molecular structures designed to selectively catalyze important biological reactions. This project will use concepts evident in enzymatic reactions to guide the synthesis of metal-organic materials with properties resembling those of reaction centers in proteins.

无机，生物无机和有机化学计划的职业奖支持俄亥俄州迈阿密大学的Hongcai Zhou教授建立包含杂环反应中心的配位网络的工作。利用金属酶的结构/性质关系指导在多孔配位聚合物纳米通道内构建以金属为中心的反应平台将为催化提供新的材料。在NSF的支持下，将构建具有桨轮分子框架和纳米结构人工酶的仿生反应平台。 纳米技术和生物无机反应之间的接口将是研究项目和本科生和研究生的新课程的核心。 新学年课程的另一个成果将是一个夏季讲习班，涉及纳米技术和生物启发合成，该讲习班将向高中生开放，由迈阿密大学的学生领导。 天然酶的能力提供了设计用于选择性催化重要生物反应的复杂分子结构的例子。 该项目将使用酶反应中明显的概念来指导具有类似于蛋白质反应中心的性质的金属有机材料的合成。