QuBIC: Molecular Robotics for DNA Nanostructures

EIA-0218359郝燕杜克大学DNA纳米结构分子机器人本项目的目标是开发分子马达，将其纳入自组装DNA晶格。该项目的主要目标将是开发新型DNA马达（如设计为具有平移和旋转运动的DNA马达）的构建的实验性概念验证演示。将分子马达整合到DNA阵列中有许多应用：它可以使用排列在DNA瓦片阵列上的分子马达装置选择性地操纵分子;马达的DNA阵列可以提供一种机制来进行其元素（瓦片）保持状态的阵列的DNA计算;并行细胞自动机计算可以从每个保持状态的有限状态自动机阵列执行。该项目还在开发含有马达的DNA纳米结构，这些马达可以在不改变环境的情况下自主运行。正在测试使用“燃料DNA”提供能量以驱动DNA纳米结构运动的方法。作为替代方法，进行实验以将蛋白质马达如驱动蛋白并入DNA晶格中。特别是，将测试使用选择性适体结合将蛋白质马达连接到DNA晶格的周期性位点。由此产生的蛋白质马达阵列在纳米机器人中有许多应用，例如，它们对于纳米颗粒的分选和运输可能非常有用。

EIA-0218359Hao Yan Duke UniversityMolecular Robotics for DNA NanostructuresThe objective of this project is to develop molecular motors that are incorporated into self-assembled DNA lattices. The main goal of this project will be to develop experimental proof-of concept demonstrations of the construction of novel DNA motors such as a DNA motor that is designed to have both translational and rotational motion. Incorporation of molecular motors into DNA arrays has many applications: It can selectively manipulate molecules using molecular motor devices arranged on DNA tiling arrays; A DNA array of motors may offer a mechanism to do DNA computation of arrays whose elements (the tiles) hold state; Parallel cellular automata computation may be executed from arrays of finite state automata each of which hold state. This project is also developing DNA nanostructures containing motors that operate autonomously without environmental changes. Methods are being tested to use "fuel DNA" to provide energy to drive the motion of DNA nanostructures. As an alternative approach, experiments are conducted to incorporate protein motors such as Kinesin into DNA lattices. In particular, the use of selective aptamer binding to link protein motors to periodic sites of a DNA lattice will be tested. The resulting arrays of protein motors have many applications to nanorobotics, e.g., they are potentially very useful for sorting and transport of nanoparticles.