NANO: Combinatorial Self-assembly of Nanocircuits on Addressable DNA Nanoscaffolds

这项提议旨在开发高度可编程和高效的.自下而上。构建纳米电子电路的方法，使用DNA纳米结构作为支架，以序列特定的分子光刻为工具，将金属和半导体纳米线组合组织成具有自组装功能的纳米电子器件的潜在应用。设计型DNA纳米支架正在成为制造复杂纳米材料的首选材料，这些材料具有潜在的对纳米级物体进行可寻址图案的能力，但它们与功能纳米材料的成功集成需要跨学科的研究。拟议研究的智力价值：合理定义的纳米电子电路图案的程序化和高效自组装目前是纳米技术中的突出挑战之一。该合作项目的主要研究目标是证明利用基于DNA的自组装可以实现可寻址分子光刻模板的自组装。已经组建了一个团队，他们的集体专业知识可以全面解决将DNA纳米结构开发为金属和半导体纳米线整体的空间可寻址模板方面最紧迫的问题。通过这项拟议的研究将实现两个主要目标：1)设计和演示DNA纳米结构的自组装，以形成包含序列特异性模板的图案化晶格，用于基于DNA的分子光刻。2)弥合基于DNA的分子光刻和DNA自组装研究之间的差距，开发高可编程纳米电路的组合方法。自下而上。集合。拟议研究的更广泛影响：该项目的更广泛影响包括对未来集成电路和微处理器生产的潜在重大影响。对学生进行有关构建纳米电子系统的各个方面的教育将产生额外的影响。将继续努力招收代表性不足的学生，包括少数族裔和妇女，并对他们进行DNA纳米技术培训。本科生和高中生也将被招募到这个项目中。我们的成果将通过各种科学出版物、与工业合作伙伴的互动以及杜克大学纳米科学和材料中心进行分发。将设计一套连贯的课程，解决纳米级计算机设备研究的重要方面。其中包括DNA纳米技术、纳米电子器件和建筑方面的主题。作为另一个重要的教育组成部分，一个基于DNA的纳米技术网站。将针对普通大众受众进行设计。PI和Co-PI.接触有才华的计算机科学专业学生，使我们能够实现这样一个具有用户友好界面的网站。DNA纳米技术的影响可以通过将拟议的研究与补充培训和知识转移方案相结合来充分发挥其潜力。一个基于网络的渠道将有助于在公共领域推广DNA纳米技术。这项建议符合以下EMT主题：通过纳入纳米科学和工程的见解来提高计算机和信息科学以及工程的基本能力。

This proposal aims to develop highly programmable and efficient .bottom-up. methods for constructing nanoelectronic circuits, using DNA nanoarchitectures as scaffolds and sequence specific molecular lithography as a tool to combinatorially organize metallic and semiconducting nanowires into rationally designed ensembles with potential applications of self-assembling functional nanoelectronic devices. Designer DNA nanoscaffolds are emerging as the material of choice for creating sophisticated nanopatterns with the potential capability to pattern nano-scale objects with addressability, but their successful integration with functional nanomaterials requires interdisciplinary studies. Intellectual merit of proposed research: The programmed and efficient self-assembly of rationally defined nanoelectronic circuit patterns is presently one of the outstanding challenges in nanotechnology. The main research objective of this collaborative project is to demonstrate that self-assembly of addressable molecular lithographic template can be achieved using DNA based self-assembly. A team has been assembled whose collective expertise can comprehensively address the most pressing issues in developing DNA nano-architectures as spatially addressable templates for metallic and semiconducting nanowire ensembles. Two main goals will be achieved through this proposed research: 1) Design and demonstrate self-assembly of DNA nanostructures to form patterned lattices containing sequence specific template for DNA based molecular lithography. 2) Bridge the gap between researches in DNA based molecular lithography and DNA self-assembly to develop combinatorial methods for highly programmable nanoelectronic circuit .bottom-up. assembly. Broader impact of proposed research: The broader impacts of this project include potentially significant influence on the production of future integrated circuits and microprocessors. Additional impact will occur in educating students about the various aspects of constructing nanoelectronic systems. Efforts will be continued in recruiting underrepresented students including minorities and women and train them in DNA based nanotechnology. Undergraduate and high school students will also be recruited to this project. Distribution of our results will occur through various scientific publications, interactions with industrial partners, and through Duke University.s Center for Nano-science and Materials. A cohesive set of courses that address the important aspects of nanoscale computer device research will be designed. This includes topics in DNA Nanotechnology, Nanoelectronic Devices and Architectures. As another important educational component, a .DNA-based nanotechnology web site. aimed at a general public audience will be designed. The PI and co-PI.s access to talented computer science students enable us to implement such a web site with a user-friendly interface. The impact of DNA nanotechnology can be brought to its full potential by integrating the proposed research with a complementary training and knowledge transfer program. A Web-based channel will help promote DNA nanotechnology in the public domain. This proposal falls into the following EMT theme: advance the fundamental capabilities of computer and information sciences and engineering by incorporating insights from nanoscale science and engineering.