NSF-Europe Materials Collaboration: New Functionalized Hybrid Systems for Drug Delivery

NSF-欧洲材料合作：用于药物输送的新型功能化混合系统

• 批准号: 0503006
• 负责人: Michael Sailor
• 金额: $ 37.5万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503006&HistoricalAwards=false
• 关键词: NSF; Europe; Materials; Collaboration; New

This award from the Solid State Chemistry program in the Division of Materials Research to University of California San Diego is to develop a chemically modified matrix of nanocrystalline porous Si or SiO2 to increase the high surface area and free volume at the nanoscale. Chemistries to cap the pores with noble metals, polymers, proteins, and silica derived from silanols will be studied, with the ultimate goal of developing a matrix for the slow release of drug under appropriate physiological conditions. The high surface area and free volume in porous Si films would allow the loading of a large amount of drug, and different drugs will be incorporated into these microscopic particles of porous Si. Delivering drugs to specified locations in the body at specified rates is an important aspect of effective medical therapies. The proposed work will encompass new methods of trapping molecules into porous nanostructures, and new methods of monitoring the porous nanostructures using the optical properties of the materials. In particular, one-dimensional photonic crystals will be prepared whose spectral signatures can report on the amount or type of drug contained within. This proposal, which was received at NSF in response to Materials World Network solicitation, is for collaborative efforts with European partners Drs. Bernard Coq, Jean-Marie Devoisselle and Frederique Cunin of the CNRS Laboratoire de Materiaux Catalytiques et Catalyse en Chimie Organique in Montpellier, France. The Montpellier lab has played a major role in the development and commercialization of liposome-based drug delivery materials in France. This collaborative program will bring together the drug delivery expertise of the Montpellier group with the nanomaterials design expertise of the UC San Diego research group.The work will provide a highly interdisciplinary education to undergraduate, graduate, and post-doctoral students in the fields of nanotechnology, biotechnology, and pharmaceutical chemistry. Nanomaterials would be developed with this award with more sophisticated functions that could be used to more effectively deliver drugs to patients. The European collaborators of this project at the Montpellier laboratory had played a major role in the development and commercialization of liposome-based drug delivery materials in France. With this award, students will be involved in short-term and long-term exchanges and studies between the San Diego and the Montpellier labs.

该奖项由加州大学圣地亚哥分校材料研究部的固态化学项目颁发，旨在开发一种化学改性的纳米晶体多孔 Si 或 SiO2 基质，以增加纳米尺度的高表面积和自由体积。 将研究用源自硅烷醇的贵金属、聚合物、蛋白质和二氧化硅来封闭孔的化学方法，最终目标是开发一种在适当的生理条件下缓慢释放药物的基质。多孔硅薄膜的高表面积和自由体积将允许负载大量药物，并且不同的药物将被纳入这些多孔硅的微观颗粒中。以指定的速率将药物输送到体内的指定位置是有效医疗的一个重要方面。拟议的工作将包括将分子捕获到多孔纳米结构中的新方法，以及利用材料的光学特性监测多孔纳米结构的新方法。 特别是，将制备一维光子晶体，其光谱特征可以报告其中所含药物的数量或类型。该提案是 NSF 应材料世界网络征集而收到的，旨在与欧洲合作伙伴 Drs. 进行合作。法国蒙彼利埃 CNRS 材料催化与化学催化实验室的 Bernard Coq、Jean-Marie Devoisselle 和 Frederique Cunin。 蒙彼利埃实验室在法国基于脂质体的药物输送材料的开发和商业化中发挥了重要作用。 该合作项目将汇集蒙彼利埃小组的药物输送专业知识与加州大学圣地亚哥分校研究小组的纳米材料设计专业知识。这项工作将为纳米技术、生物技术和药物化学领域的本科生、研究生和博士后提供高度跨学科的教育。 该奖项将开发具有更复杂功能的纳米材料，可用于更有效地向患者输送药物。 蒙彼利埃实验室该项目的欧洲合作者在法国基于脂质体的药物输送材料的开发和商业化中发挥了重要作用。 凭借该奖项，学生将参与圣地亚哥和蒙彼利埃实验室之间的短期和长期交流和研究。