Materials World Network (MWN): Chemistry of Porous Silicon Nanoparticles for Photodynamic Therapy

技术概要：该合作项目将联合收割机结合美国同行在硅纳米技术方面的专业知识和法国同行在介孔药物递送材料、生物物理学、光动力治疗剂和前列腺癌临床光动力治疗方面的专业知识，开发基于可生物降解多孔硅纳米颗粒的光活性抗癌材料。 一个主要目标是提供更高产率的单线态氧和/或活性氧物质，以在癌细胞附近诱导不可逆的细胞损伤，用于更有效的光动力治疗（PDT）。 NSF资助的美国同行将专注于基础材料科学问题：多孔硅纳米粒子的合成，提高合成产率和PDT量子产率，以及PDT，生物相容性和靶向的最佳表面化学的开发。 法国资助的对应实验室将专注于生物学应用：靶向癌细胞内的纳米颗粒和癌细胞中的单光子和双光子PDT。 非技术总结：光动力疗法（PDT）是一种结合使用敏化剂和光来杀死癌细胞的治疗方法，已在临床上使用了十多年。 尽管治疗本身具有优势，但目前使用的光敏剂显示出限制其使用的毒性或其他副作用。 该合作项目的目标是将纳米技术的优势与光动力治疗剂结合联合收割机，以开发更有效的抗癌材料，重点是可生物降解的多孔硅纳米颗粒。来自美国的团队包括研究生，本科生和高中生。这项工作将包括美国和法国学生访问对口实验室，进行为期一个月的研究体验。 教育推广活动将包括一个“硅纳米技术暑期学校”，其中10名美国高中生将在加州大学圣地亚哥分校的实验室每年夏天举办一个月。该项目得到了生物材料计划和材料研究部特别计划办公室的支持。

TECHNICAL SUMMARY:This collaborative project will combine the U.S. counterpart's expertise in silicon nanotechnology with the French counterpart's expertise in mesoporous drug delivery materials, photophysics, photodynamic therapeutic agents, and clinical photodynamic therapy on prostate cancer to develop photoactive anti-cancer materials based on biodegradable porous silicon nanoparticles. A main goal is to provide higher yields of singlet oxygen and/or reactive oxygen species to induce irreversible cell damage in the vicinity of cancer cells for more effective photodynamic therapy (PDT). The NSF-funded U.S. counterpart will focus on fundamental materials science issues: synthesis of porous Si nanoparticles with improved synthetic yields and PDT quantum yields, and development of optimal surface chemistries for PDT, biocompatibility, and targeting. The French funded counterpart lab will focus on the biological applications: targeting of nanoparticles inside cancer cells and one- and two-photon PDT in cancer cells. NON-TECHNICAL SUMMARY:Photodynamic therapy (PDT), a treatment that combines the use of a sensitizing agent and light to kill cancer cells, has been in clinical use for over a decade. Despite the advantages of the therapy itself, photosensitizers in use today display toxic or other side effects that limit their use. The goal of the collaborative project is to combine the advantages of nanotechnology with photodynamic therapeutic agents to develop more effective anti-cancer materials and it will focus on biodegradable porous silicon nanoparticles The team from the U.S. includes graduate students, undergraduate students, and high school students. The effort will involve visits by U.S. and French students to the counterpart laboratories for month-long research experiences. The educational outreach activities will include a "Summer School for Silicon Nanotechnology," in which ten U.S. high school students will be hosted in the UCSD lab for one month every summer.This project is supported by the Biomaterials program and the Office of Special Programs, Division of Materials Research.