Materials World Network (MWN): Chemistry of Porous Silicon Nanoparticles for Photodynamic Therapy

技术概述：该合作项目将结合美国同行在硅纳米技术方面的专业知识和法国同行在介孔药物递送材料、光物理学、光动力治疗剂和前列腺癌临床光动力治疗方面的专业知识，开发基于可生物降解多孔硅纳米颗粒的光活性抗癌材料。主要目标是提供更高产量的单线态氧和/或活性氧，以诱导癌细胞附近的不可逆细胞损伤，从而实现更有效的光动力治疗（PDT）。nsf资助的美国对应项目将专注于基础材料科学问题：多孔硅纳米颗粒的合成，提高合成收率和PDT量子收率，以及PDT的最佳表面化学，生物相容性和靶向性的发展。法国资助的对应实验室将专注于生物应用：靶向癌细胞内的纳米颗粒和癌细胞内的单光子和双光子PDT。非技术总结：光动力疗法（PDT）是一种结合使用增敏剂和光来杀死癌细胞的治疗方法，已经在临床应用了十多年。尽管光敏剂本身具有优势，但目前使用的光敏剂显示出毒性或其他副作用，限制了它们的使用。该合作项目的目标是结合纳米技术和光动力治疗剂的优势，开发更有效的抗癌材料，并将重点放在可生物降解的多孔硅纳米颗粒上。来自美国的团队包括研究生、本科生和高中生。这项工作将包括由美国和法国学生访问对等实验室，进行为期一个月的研究体验。教育拓展活动将包括“硅纳米技术暑期学校”，每年夏天将有10名美国高中生在加州大学圣地亚哥分校的实验室学习一个月。本项目由生物材料项目和材料研究部特别项目办公室支持。

TECHNICAL SUMMARY:This collaborative project will combine the U.S. counterpart's expertise in silicon nanotechnology with the French counterpart's expertise in mesoporous drug delivery materials, photophysics, photodynamic therapeutic agents, and clinical photodynamic therapy on prostate cancer to develop photoactive anti-cancer materials based on biodegradable porous silicon nanoparticles. A main goal is to provide higher yields of singlet oxygen and/or reactive oxygen species to induce irreversible cell damage in the vicinity of cancer cells for more effective photodynamic therapy (PDT). The NSF-funded U.S. counterpart will focus on fundamental materials science issues: synthesis of porous Si nanoparticles with improved synthetic yields and PDT quantum yields, and development of optimal surface chemistries for PDT, biocompatibility, and targeting. The French funded counterpart lab will focus on the biological applications: targeting of nanoparticles inside cancer cells and one- and two-photon PDT in cancer cells. NON-TECHNICAL SUMMARY:Photodynamic therapy (PDT), a treatment that combines the use of a sensitizing agent and light to kill cancer cells, has been in clinical use for over a decade. Despite the advantages of the therapy itself, photosensitizers in use today display toxic or other side effects that limit their use. The goal of the collaborative project is to combine the advantages of nanotechnology with photodynamic therapeutic agents to develop more effective anti-cancer materials and it will focus on biodegradable porous silicon nanoparticles The team from the U.S. includes graduate students, undergraduate students, and high school students. The effort will involve visits by U.S. and French students to the counterpart laboratories for month-long research experiences. The educational outreach activities will include a "Summer School for Silicon Nanotechnology," in which ten U.S. high school students will be hosted in the UCSD lab for one month every summer.This project is supported by the Biomaterials program and the Office of Special Programs, Division of Materials Research.