UC San Diego MRSEC: an NSF Materials Research Science and Engineering Center

加州大学圣地亚哥分校 MRSEC：NSF 材料研究科学与工程中心

• 批准号: 2011924
• 负责人: Michael Sailor
• 金额: $ 1800万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2011924&HistoricalAwards=false
• 关键词: UC; San; Diego; MRSEC; NSF

Nontechnical Abstract: The growth, prosperity, security, and quality of life of humans are in large part determined by the materials they use. The mission of the UC San Diego Materials Research Science and Engineering Center (UCSD MRSEC) is to perform innovative, interdisciplinary materials research relevant to societal needs, and to prepare students to become future leaders in materials design and discovery. The research effort of the Center is conducted within two highly interdisciplinary groups. The first group is deploying the most powerful computers available to understand, predict, and ultimately control the properties of materials at microscopic size scales—sizes just larger than molecular dimensions. It is in this size regime where many useful properties of materials emerge. For example, changes in the shape of metal particles at this scale can change their color, their efficiency as a catalyst, or their sensitivity in a medical diagnostic test. The second group is using the tools of the biotechnology revolution—in particular, genetic engineering and synthetic biology—to build new classes of materials that can respond to stimuli from their environment in useful ways. Both groups are targeting fundamental breakthroughs that can impact a number of critically important needs: faster, more accurate sensors for medical diagnostic tests, more efficient decontamination of chemical or biological hazards, better catalysts to reduce the cost of industrial processes, and improved therapeutics for treating diseases. The fundamental research within the two groups is empowered by an integrated educational program to prepare a diverse community of trainees to enhance national proficiencies in the science, technology, engineering, and mathematics fields. Immersive training for scientists across all levels – novice through established – develops technical competency in laboratory procedures, advanced instrumentation, and computational methods. Internship and scientist-in-residence programs fuel vital exchange of ideas and leverage partnerships with industry, national laboratories, and other collaborators. Partnership with the Fleet Science Center builds researchers’ skills in science communication and connects the UCSD MRSEC with the diverse San Diego community to address community-articulated needs. Technical Abstract: The UCSD MRSEC addresses two fundamental challenges: (1) How to predict and direct the assembly of materials at the mesoscale, where macroscopic behavior and properties emerge (IRG1: Predictive Assembly); and (2) How to deploy the tools of synthetic biology to build soft materials that meld the characteristics of living systems with the performance requirements of advanced engineered materials (IRG2: Stimuli-Responsive Living Polymeric Materials). IRG1 focuses on the rational design of innovative, functional mesomaterials with programmed plasmonic, catalytic, and structural properties. A computation-driven framework is being created to understand, predict, and design how shaped nanocomponents are used as material building blocks. The models developed bridge length and time scales relevant to mesoscale assembly. IRG2 integrates engineered living matter – photosynthetic organisms – into biological composites that respond to stimuli with genetically encoded outputs, such as chemical reagents and polymer feedstocks. The UCSD MRSEC creates unique resources to benefit the broader materials-research community: a MesoMaterials Design Facility – a virtual, computational facility, and an Engineered Living Materials Foundry, consisting of a bio-synthesis laboratory and soft-matter characterization tools. The Center’s educational goals include preparing the next generation of interdisciplinary materials scientists, and increasing diversity and inclusion in materials research. The Research Immersion in Materials Science and Engineering (RIMSE) Summer Schools provide intensive training in the areas of IRG research. Enabling professional development for Center members in science communication, a partnership with the Fleet Science Center facilitates meaningful engagement with the diverse San Diego community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要：人类的成长、繁荣、安全和生活质量在很大程度上取决于他们所使用的材料。加州大学圣地亚哥分校材料研究科学与工程中心(UCSD MRSEC)的使命是进行与社会需求相关的跨学科创新材料研究，并培养学生成为未来材料设计和发现领域的领导者。该中心的研究工作是在两个高度跨学科的小组内进行的。第一组正在部署可用的最强大的计算机，以了解、预测并最终控制微观尺寸的材料的性质-尺寸仅大于分子尺寸。正是在这种大小范围内，材料出现了许多有用的特性。例如，在这种尺度下，金属颗粒形状的变化可以改变它们的颜色，它们作为催化剂的效率，或者它们在医学诊断测试中的灵敏度。第二组正在使用生物技术革命的工具--特别是基因工程和合成生物学--来构建能够以有用的方式对环境刺激做出反应的新材料类别。这两个组织的目标都是能够影响到一些至关重要的需求的根本性突破：用于医疗诊断测试的更快、更准确的传感器，更有效地去除化学或生物危害的污染，更好的催化剂来降低工业流程的成本，以及治疗疾病的改进疗法。这两个小组的基础研究是由一个综合教育计划提供支持的，该计划旨在培养一个多样化的受训群体，以提高国家在科学、技术、工程和数学领域的熟练程度。为所有级别的科学家提供身临其境的培训--从新手到老手--培养实验室程序、先进仪器和计算方法方面的技术能力。实习和驻院科学家计划促进了重要的思想交流，并利用了与行业、国家实验室和其他合作者的伙伴关系。与舰队科学中心的伙伴关系培养了研究人员在科学交流方面的技能，并将加州大学圣迭戈分校的MRSEC与圣地亚哥的不同社区联系起来，以满足社区表达的需求。技术摘要：UCSD MRSEC解决了两个基本挑战：(1)如何预测和指导材料在介观尺度上的组装，宏观行为和性质出现在那里(IRG1：预测性组装)；(2)如何利用合成生物学的工具来构建将生命系统的特征与先进工程材料的性能要求相结合的软材料(IRG2：刺激响应型活性聚合物材料)。IRG1致力于合理设计具有程序等离子体、催化和结构特性的创新功能介孔材料。正在创建一个计算驱动的框架，以了解、预测和设计形状的纳米组件如何用作材料构建块。这些模式发展了与中尺度组装相关的桥梁长度和时间尺度。IRG2将工程生物--光合作用有机体--集成到生物复合体中，这些生物复合体以遗传编码的输出对刺激做出反应，例如化学试剂和聚合物原料。UCSD MRSEC创造了独特的资源，使更广泛的材料研究社区受益：介观材料设计设施-一个虚拟的计算设施，以及一个工程生物材料铸造，由一个生物合成实验室和软物质表征工具组成。该中心的教育目标包括培养下一代跨学科材料科学家，增加材料研究的多样性和包容性。材料科学与工程研究沉浸式(RIMSE)暑期学校提供IRG研究领域的强化培训。为了促进中心成员在科学交流方面的专业发展，与舰队科学中心的合作伙伴关系促进了与圣地亚哥多样化社区的有意义的接触。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Fabrication of an inexpensive injection molding instrument for rapid prototyping of high precision parts

• DOI: 10.1016/j.polymer.2022.125521
• 发表时间: 2022-11
• 期刊: Polymer
• 影响因子: 4.6
• 作者: David M. Wirth;Leonard G. McCline;J. Pokorski

Bioconjugation of Active Ingredients to Plant Viral Nanoparticles Is Enhanced by Preincubation with a Pluronic F127 Polymer Scaffold

• DOI: 10.1021/acsami.1c13183
• 发表时间: 2021-12-10
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Shin, Matthew D.;Hochberg, Justin D.;Steinmetz, Nicole F.
• 通讯作者: Steinmetz, Nicole F.

Computational Modeling of Molecular Mechanics for the Experimentally Inclined

• DOI: 10.1021/acs.chemmater.2c00292
• 发表时间: 2022-08
• 期刊: Chemistry of Materials
• 影响因子: 8.6
• 作者: Andrew T. Kleinschmidt;Alexander X. Chen;T. Pascal;D. Lipomi

Effect of variations in manufacturing and material properties on the self-folding behaviors of hydrogel and elastomer bilayer structures

制造和材料性能变化对水凝胶和弹性体双层结构自折叠行为的影响

• DOI: 10.1039/d2sm01104b
• 发表时间: 2022
• 期刊: Soft Matter
• 影响因子: 3.4
• 作者: Zhao, Jiayu;Kazemi, Hesaneh;Kim, H. Alicia;Bae, Jinhye
• 通讯作者: Bae, Jinhye

Stereoselective Growth of Small Molecule Patches on Nanoparticles.

• DOI: 10.1021/jacs.1c04272
• 发表时间: 2021-07
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Jiajing Zhou;Matthew N Creyer;Amanda A Chen;Wonjun Yim;René P. M. Lafleur;Tengyu He;Zhixing Lin