MRI: Acquisition of an NMR Spectrometer to Support Undergraduate Research and Curriculum Reform

在主要研究仪器(MRI)计划的支持下，伊萨卡学院化学系将获得一台300 MHz核磁共振(核磁共振)光谱仪。该设备将使研究人员能够开展以下研究：a)稳定的、缺乏电子的二价硅物种的合成和表征；b)氧和碳之间质子转移的动力学和机理研究；c)抗菌药物的发现；d)基于Ru的烯烃聚合/小分子活化催化剂的开发；以及e)用于组织工程研究的树枝状大分子的合成。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对药物化学、生物技术和聚合物合成产生影响。

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Ithaca College will acquire a 300 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) the synthesis and characterization of stable, electron-deficient divalent silicon species; b) kinetic and mechanistic studies of proton transfer between oxygen and carbon; c) antibacterial drug discovery; d) development of Ruthenium-based olefin polymerization/small molecule activation catalysts; and e) the synthesis of dendrimers used in tissue engineering studies. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in medicinal chemistry, biotechnology and polymer synthesis.