MRI: Acquisition of Dual-Probe Near Field Scanning Optical Microscope for Dynamic Molecular Mapping of Cytoskeletal Force Generation
MRI:获取双探头近场扫描光学显微镜,用于细胞骨架力生成的动态分子图谱
基本信息
- 批准号:0521122
- 负责人:
- 金额:$ 21.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-08-15 至 2007-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0521122VanVlietThe objective is to acquire a dual probe-near field scanning optical microscope to enable fundamental investigations of cytoskeletal protein-based force generation through close collaboration among PIs in three academic departments who address this scientific issue with distinct expertise. Two specific research projects, which will benefit significantly from the capabilities of the DP-NSOM, are presented. Acquisition of the DP-NSOM will directly enable substantive collaborations among three academic departments at the Massachusetts Institute of Technology and the Whitehead Institute. This acquisition will also provide significantly enhanced experimental capabilities to two junior faculty whose research groups each apply engineering principles to the study of cellular and molecular mechanics. Further, this DP-NSOM will be a vital experimental component of proposed cross-departmental collaborations among these and additional investigators, focusing on analytical and computational modeling of cytoskeletal mechanics. This acquisition will also significantly contribute to MIT's initiatives in cross-disciplinary education. In addition to research training of graduate students and postdoctoral fellows, educational efforts within MIT will include new graduate- and undergraduate-level laboratory modules.
0521122 VanVliet的目标是获得一个双探针近场扫描光学显微镜,使细胞骨架蛋白质为基础的力的产生,通过在三个学术部门谁解决这个科学问题与独特的专业知识PI之间的密切合作的基础研究。两个具体的研究项目,这将大大受益于DP-NSOM的能力,提出。DP-NSOM的收购将直接使马萨诸塞州理工学院和怀特黑德研究所的三个学术部门之间的实质性合作成为可能。此次收购还将为两名初级教师提供显著增强的实验能力,他们的研究小组各自将工程原理应用于细胞和分子力学的研究。此外,这个DP-NSOM将是这些和其他研究人员之间拟议的跨部门合作的一个重要实验组成部分,重点是细胞骨架力学的分析和计算建模。这次收购也将大大有助于麻省理工学院在跨学科教育的举措。除了研究生和博士后研究员的研究培训,麻省理工学院的教育工作将包括新的研究生和本科生水平的实验室模块。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Krystyn Van Vliet其他文献
The Origin and Limits of Natural Variation in Cell Mechanical Behavior
- DOI:
10.1016/j.bpj.2010.12.2603 - 发表时间:
2011-02-02 - 期刊:
- 影响因子:
- 作者:
John M. Maloney;Krystyn Van Vliet - 通讯作者:
Krystyn Van Vliet
Macromolecular Crowding Facilitates Adipogenic Microenvironments for Human Mesenchymal Stem Cells
- DOI:
10.1016/j.bpj.2010.12.3578 - 发表时间:
2011-02-02 - 期刊:
- 影响因子:
- 作者:
Felicia C. Loe;Krystyn Van Vliet;Michael Raghunath - 通讯作者:
Michael Raghunath
Krystyn Van Vliet的其他文献
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{{ truncateString('Krystyn Van Vliet', 18)}}的其他基金
CAREER: Chemomechanical imaging and engineering of single cell phenotype
职业:单细胞表型的化学机械成像和工程
- 批准号:
0644846 - 财政年份:2007
- 资助金额:
$ 21.5万 - 项目类别:
Continuing Grant
NER: Dynamic Nanomechanical Mapping of Living Cell Surface Receptors
NER:活细胞表面受体的动态纳米力学绘图
- 批准号:
0508220 - 财政年份:2005
- 资助金额:
$ 21.5万 - 项目类别:
Standard Grant
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