MRI: Acquisition of a Dual-Source Single-Crystal X-ray Diffractomter

该奖项由主要研究仪器和化学仪器计划支持。来自南达科他州（USD）大学的Andrew Sykes教授及其同事Haoran Sun和Zhenqiang Wang正在购买一台双源单晶衍射仪。一般来说，X射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响了许多领域，包括有机和无机化学，材料化学和生物化学。该仪器是教学的一个组成部分，以及研究和研究培训的本科生和研究生在化学和生物化学在这个和其他合作机构。因为这是该州唯一的衍射设施，它作为一个区域资源。衍射仪还可以在地区学院和部落学校培训本科生，这些学院和部落学校通过本科生研究经验（REU）计划与本地机构建立了长期关系。该工具还被广泛用于教育和培训代表性不足的学生，如来自内布拉斯加州印第安社区学院（NICC，在南苏城，梅西和桑蒂，NE）的美国土著学生，他们参加了在USD的夏季研究。这对于研究甾体化合物的绝对结构和分析具有潜在生物医学应用的无机近红外活性染料特别有用。该衍射仪还用于确定用于碳-氟催化的两亲性（洗涤剂样）分子的结构。该仪器已用于阴离子传感器、荧光压力传感器和蒽醌亚胺阳离子荧光传感器的研究。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Andrew Sykes from the University of South Dakota (USD) and colleagues Haoran Sun and Zhenqiang Wang are acquiring a dual-source single-crystal diffractometer. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this and other collaborating institutions. Because this is the only diffraction facility in the state it serves as a regional resource. The diffractometer also enables training of undergraduates at regional colleges and tribal schools with whom the home institution has long-established relationships through Research Experiences for Undergraduates (REU) programs. The instrument is also used extensively in the education and training of underrepresented students such as Native American students from Nebraska Indian Community College (NICC, in South Sioux City, Macy and Santee, NE) who participate in summer research at USD.The award is aimed at enhancing research and education at all levels. It is especially useful for studying the absolute structure of steroids and for analyzing inorganic near-infrared active dyes with potential biomedical applications. The diffractometer is also employed to determine the structure of amphiphilic (detergent-like) molecules used in carbon-fluorine catalysis. The instrument is utilized in studies of anion sensors, fluorescent pressure sensors and anthraquinone-imine cation fluorescent sensors. It is also employed to characterize perfluoroalkylated transition metal complexes and metal-organic supercontainers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.