Investigation of Enantioselective Adsorption on Chiral Mineral Surfaces

手性矿物表面对映选择性吸附的研究

• 批准号: 0521719
• 负责人: Paul Sides
• 金额: --
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521719&HistoricalAwards=false
• 关键词: Investigation; Enantioselective; Adsorption; Chiral; Mineral

Proposal Title: Investigation of Enantioselective Adsorption on Chiral Mineral SurfacesProposal Number: CTS-0521719Principal Investigator: Paul SidesInstitution: Carnegie Mellon UniversityThe objective of this proposal is to demonstrate that chiral surfaces of minerals can function as enantioselective analysis and separations media. Many common inorganic materials have chiral bulk structures. Fundamental evidence for the enantiospecific adsorption of amino acids on single crystalline quartz and calcite will be produced. Ultra-high vacuum surface science tools will be used to quantify the differences in the adsorption energies of R- and S- amino acids onto chiral surfaces of quartz and calcite. The extent of the adsorption will be evaluated in vacuum by temperature programmed desorption and in aqueous solutions by detection of the zeta potential differences between surfaces of opposite handedness when amino acids are adsorbed. The zeta potential measurements will be made using a novel technique recently developed at Carnegie Mellon University. This technique will be adapted to make a differential measurement of enantioselective adsorption on R- and S- surfaces. Enantioselective adsorption on mineral surfaces has never before been studied under the controlled conditions possible in ultrahigh vacuum. The second novel feature is the use of a rotating disk method recently invented for measuring changes in zeta potential of inorganic surfaces associated with adsorption of charged molecules such as amino acids; this method makes possible a true differential measurement of enantioselectivity. The proposed investigation will contribute to the fundamental understanding of the enantiospecific adsorption of chiral compounds on inorganic chiral surfaces. In terms of the broader impacts, the proposed investigation will foster dissemination of knowledge about chirality, a subtle aspect of molecular structure that engineering disciplines such as materials science and chemical engineering have largely ignored. A new experiment based on enantiospecific adsorption will be incorporated in an existing laboratory course. This work could lead to better processes for performing separations of chiral molecules for use in pharmaceuticals, artificial flavors, and agrochemicals.

提案标题：手性矿物表面对映体选择性吸附的研究提案编号：CTS-0521719首席研究员：Paul Sids研究所：卡内基梅隆大学这项提案的目的是证明矿物的手性表面可以作为对映体选择性分析和分离介质。许多常见的无机材料都具有手性体相结构。将产生氨基酸在单晶石英和方解石上对映体特异性吸附的基本证据。超高真空表面科学工具将被用来量化R-和S-氨基酸在石英和方解石手性表面上的吸附能差异。吸附的程度将在真空中通过程序升温脱附和在水溶液中通过检测氨基酸被吸附时相反手表面之间的Zeta电位差来评估。Zeta电势的测量将使用卡内基梅隆大学最近开发的一项新技术。该技术将用于R-和S-表面对映体选择性吸附的差示测量。在超高真空条件下，对映体在矿物表面的选择性吸附以前从未被研究过。第二个新颖的特征是使用最近发明的旋转圆盘方法来测量与氨基酸等带电分子的吸附相关的无机表面的Zeta电位的变化；该方法使得对映体选择性的真正差示测量成为可能。这项研究将有助于对手性化合物在无机手性表面上对映体专一性吸附的基本理解。就更广泛的影响而言，拟议的调查将促进手性知识的传播，手性是分子结构的一个微妙方面，而材料科学和化学工程等工程学科在很大程度上忽视了这一点。一项基于对映体特异性吸附的新实验将被纳入现有的实验室课程。这项工作可能导致更好的分离手性分子的工艺，用于制药、人工香精和农用化学品。