Endosomal Protein Transport: From Molecular Structures to Biological Function

生物分子通过内体细胞器的细胞内运输对于正常的细胞过程，如信号传递、稳态和发育是至关重要的。这一基本过程中的缺陷以及细菌和病毒病原体对其的颠覆也会导致许多不同的人类疾病。该项目将建立在澳大利亚强大的结构和细胞生物学研究方案的基础上，以在分子一级对内体贩运形成关键见解。这项工作的结果将使澳大利亚站在了解这一重要生物学过程的国际努力的前沿，并将对未来的药物设计产生重要影响。

Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.