Endosomal Protein Transport: From Molecular Structures to Biological Function

内体蛋白质运输：从分子结构到生物功能

• 批准号: DP0985029
• 负责人: Prof Brett Collins
• 金额: $ 20.06万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985029
• 关键词: Endosomal; Protein; Transport; Molecular; Structures

Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.

生物分子通过内体细胞器的细胞内转运对于正常的细胞过程，例如信号，同性恋和发育至关重要。细菌和病毒病原体对此的基本过程及其颠覆的缺陷也导致许多不同的人类疾病。该项目将基于澳大利亚强大的结构和细胞生物学研究计划，以在分子水平上发展对内体贩运的关键见解。这项工作的结果将使澳大利亚成为了解这一基本生物学过程的国际努力的最前沿，并将对药品的未来设计具有重要意义。