Lipid droplet membrane tethers at atomic resolution

原子分辨率下的脂滴膜系链

• 批准号: DP200102551
• 负责人: Prof Brett Collins
• 金额: $ 31.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102551
• 关键词: Lipid; droplet; membrane; tethers; atomic

Eukaryotic cells are distinguished by the presence of membrane-bound compartments called organelles. This project will use structural biology to determine how essential proteins called sorting nexins (SNXs) regulate membrane interactions required for lipid droplet formation. These interactions are essential for life, controlling protein and lipid homeostasis needed for cell survival. The major outcome of this proposal will be a fundamental understanding of how SNXs control this process, and the work will significantly strengthen our international collaboration in this emerging area. The knowledge has potential future translation in the treatment of neurodegenerative disorders where dysregulation of these proteins is known to cause disease.

真核细胞的区别在于存在称为细胞器的膜结合区室。该项目将使用结构生物学来确定称为分选连接蛋白（SNX）的重要蛋白质如何调节脂滴形成所需的膜相互作用。这些相互作用对生命至关重要，控制细胞生存所需的蛋白质和脂质稳态。该提案的主要成果将是对SNX如何控制这一过程的基本了解，这项工作将显着加强我们在这一新兴领域的国际合作。这些知识在神经退行性疾病的治疗中具有潜在的未来翻译，已知这些蛋白质的失调会导致疾病。