The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking

内体膜运输中逆转录酶和分选连接蛋白功能的分子机制

• 批准号: DP0664092
• 负责人: Prof Brett Collins
• 金额: $ 14.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-05-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664092
• 关键词: molecular; mechanism; retromer; sorting; nexin

The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.

拟议的研究代表了突破性科学，这将导致在逆转录复合物结构和组装的分子水平上的基本理解，以及它如何调节内体系统中受体的分类。它将为构成最新结构和分子细胞生物学研究的多学科方法的顶级研究生和博士后科学家提供出色的研究培训。通过在国际上解决一个引人注目的领域，该项目将有能力提高澳大利亚的知识库，并增强其在卓越研究方面的声誉。