Structural basis for the assembly of caveolae

小窝组装的结构基础

• 批准号: DP150100505
• 负责人: Prof Brett Collins
• 金额: $ 35.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100505
• 关键词: Structural; basis; assembly; caveolae

Caveolae are small invaginations of the plasma membrane and are a characteristic feature of eukaryotic cells. Described morphologically in the early 1950s their many important functions are only just beginning to be revealed. Caveolae are multifunctional organelles that play a vital role in normal cellular processes such as signalling and membrane homeostasis, and are perturbed in cancer, lipid storage and muscle diseases. A new family of coat proteins called cavins have recently been discovered. Cavins are essential for the formation of caveolae, and this project seeks to understand how these multiprotein complexes are assembled at the membrane interface and control caveola function at the molecular level.

小窝是质膜的小内陷，是真核细胞的特征。在20世纪50年代早期，它们的许多重要功能才刚刚开始被揭示出来。小窝是多功能的细胞器，在正常的细胞过程中起着至关重要的作用，如信号传导和膜稳态，并在癌症，脂质储存和肌肉疾病中受到干扰。最近发现了一个新的外壳蛋白家族，称为cavins。Cavins对于小窝的形成至关重要，该项目旨在了解这些多蛋白复合物如何在膜界面组装并在分子水平上控制小窝功能。