Total Synthesis of Lytophilippine A

天然产物Lytophilippine A是从带刺的水生动物Lytocarpus philippinus中分离得到的一种海洋多酮化合物。红海水母的天然产物化学还很少被研究。大量的手性碳原子是Lytophilippine A分子结构的定义和区别元素，对不对称合成构成了巨大的挑战。最初关于Lytophilippine A的结构的建议被全合成证伪，并且需要修改绝对构型的指认。基于我们大量的实验基础，本项目建议完成(11R，13R，14R，15R)构型的Lytophilippine A及其几个(13，14，15)非对映异构体的全合成。随着全合成的完成，我们的目标是对最终的结构分配做出重大贡献，并使进一步研究天然产物的生物学特性成为可能。通过为我们的总合成研究计划选择一个具有特殊分子复杂性的目标，我们打算将合成科学的前沿推向最先进的水平，甚至可能更高。

The natural product lytophilippine A is a marine polyketide that was isolated from the stinging hydroid Lytocarpus philippinus. The natural product chemistry of the Red Sea hydroid has yet been sparsely investigated. The large number of chiral carbon atoms is the defining and distinguishing element of the molecular architecture of lytophilippine A, and constitutes a significant challenge for asymmetric synthesis. The original proposal for the structure of lytophilippine A was falsified by total synthesis and a revision of the assignment of the absolute configuration is required. Based on our massive experimental groundwork, this project suggests the completion of the total synthesis of the (11R,13R,14R,15R)-configured lytophilippine A and several of its (13,14,15)-diastereomers. With the completion of the total synthesis, we aim to contribute significantly to the final structural assignment and enable further investigation of the biological properties of the natural product. By selecting a target of unusual molecular complexity for our total synthesis research program, we intent to push the frontiers of the science of synthesis to the state of the art and possibly beyond.