CAREER: Interfacing and Integrating Life-Sciences and Solid-Mechanics

职业：生命科学和固体力学的连接和集成

• 批准号: 0547094
• 负责人: Kai-tak Wan
• 金额: --
• 依托单位: Missouri University of Science and Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547094&HistoricalAwards=false
• 关键词: CAREER; Interfacing; Integrating; Life; Sciences

Interfacing and Integrating Life-Sciences and Solid-Mechanics Dr. Kai-tak Wan, Mechanical Engineering, University of Missouri-RollaSolid-mechanics is incorporated into life-sciences to complement the conventional biochemical approach and to open new grounds for engineering research. Investigations in micro-mechanics and micro-structure of artificial, porcine and human eyes and ocular lenses will enhance fundamental understanding and bio-technology development in ophthalmic accommodation mechanics, presbyopia, prosthetic lenses for cataract eyes, retina detachment due to diabetes etc. Mechanical characterization of single cells and thin biomembranes will improve understanding in how cells deform and adhere to form multi-cell aggregate and ultimately 3-dimensional tissues. The work delves into the mechanical aspects of stem cell chondrogenesis, morphogenesis and developmental biology. Theoretical modeling and experimentation will be carried out at various medical schools and hospitals. The trans-disciplinary and inter-institutional project forges collaboration between mechanics and biomedical communities. An education program promotes Life-Science based Solid-Mechanics in engineering and medical schools.

生命科学与固体力学的结合与整合密苏里大学机械工程系温启德博士将固体力学与生命科学结合起来，以补充传统的生物化学方法，并为工程研究开辟新的领域。对人造、猪和人类眼睛以及眼晶状体的微观力学和微观结构的研究将增强对眼调节力学、老花眼、白内障眼人工晶状体、单细胞和薄生物膜的机械特性将提高对细胞如何变形和粘附以形成多细胞膜的理解。细胞聚集并最终形成三维组织。这项工作深入研究了干细胞软骨形成，形态发生和发育生物学的机械方面。将在各医学院和医院进行理论建模和实验。这个跨学科和跨机构的项目促进了力学和生物医学界之间的合作。一个教育计划，促进生命科学为基础的固体力学在工程和医学院。