CAREER: Interfacing and Integrating Life-Sciences and Solid-Mechanics

生命科学与固体力学的结合温启德博士，机械工程，密苏里大学罗拉分校固体力学与生命科学相结合，以补充传统的生化方法，并为工程研究开辟新的领域。对人工、猪、人的眼睛和晶状体的微观力学和微观结构的研究将促进对眼科调节力学、老花眼、白内障人工晶状体、糖尿病视网膜脱离等方面的基本认识和生物技术的发展。单细胞和薄生物膜的力学特性将提高对细胞如何变形和粘附形成多细胞聚集体并最终形成三维组织的理解。这项工作深入研究了干细胞软骨形成、形态发生和发育生物学的机械方面。理论建模和实验将在各医学院和医院进行。跨学科和跨机构的项目锻造力学和生物医学界之间的合作。一项教育计划在工程和医学院促进基于生命科学的固体力学。

Interfacing and Integrating Life-Sciences and Solid-Mechanics Dr. Kai-tak Wan, Mechanical Engineering, University of Missouri-RollaSolid-mechanics is incorporated into life-sciences to complement the conventional biochemical approach and to open new grounds for engineering research. Investigations in micro-mechanics and micro-structure of artificial, porcine and human eyes and ocular lenses will enhance fundamental understanding and bio-technology development in ophthalmic accommodation mechanics, presbyopia, prosthetic lenses for cataract eyes, retina detachment due to diabetes etc. Mechanical characterization of single cells and thin biomembranes will improve understanding in how cells deform and adhere to form multi-cell aggregate and ultimately 3-dimensional tissues. The work delves into the mechanical aspects of stem cell chondrogenesis, morphogenesis and developmental biology. Theoretical modeling and experimentation will be carried out at various medical schools and hospitals. The trans-disciplinary and inter-institutional project forges collaboration between mechanics and biomedical communities. An education program promotes Life-Science based Solid-Mechanics in engineering and medical schools.