Tunneling Spectroscopy for Nanofabricated Biochemical Sensors

[0601269willisabstract]这一综合系统方案侧重于纳米分子隧道结的科学和工程，以创造新的化学-生物传感器。这个跨部门、跨学科的研究项目解决了对低成本、便携式传感设备新概念的需求，这些设备可以防止环境危害和有毒化学生物制剂。该研究将研究用于固态传感器器件的纳米隧道结和非弹性电子隧道光谱（IETS）。与现有概念相比，这项工作的优点包括：(1)灵敏度低至单分子水平，(2)所有固态结构允许集成到复杂的混合系统中，(3)有利于低成本制造的设备设计，以及(4)未知分子制剂的光谱识别。该研究将研究纳米制造技术与原子层化学的新结合，以设计1-2纳米间隔的金属-分子-金属隧道结，该隧道结将被掺杂模型化合物，并用IETS进行光谱鉴定。该研究项目的智力优势在于分子器件的基础科学，包括对分子-电极化学相互作用和单分子器件的电荷传输的理解。特别是，需要实验数据来连接单分子隧道结的物理性质和电测量。IETS提供了对纳米制造结的分子结构的探测，这将推动基于分子的器件的科学和工程。该研究项目的广泛影响对未来基于分子装置的技术具有重要意义，这些技术使低成本、无处不在的传感器能够保护公众免受环境危害和有毒化学生物制剂的侵害。此外，该研究计划将通过多媒体演示与公众互动，展示纳米技术的具体例子。

0601269WillisAbstractThis integrative systems proposal focuses on the science and engineering of nanofabricated molecular tunnel junctions to create novel chemical-biological sensors. The cross-departmental, interdisciplinary research program addresses the need for new concepts in low cost, portable sensing devices that can protect against environmental hazards and toxic chemical-biological agents. The research will investigate nanofabricated tunnel junctions and inelastic electron tunneling spectroscopy (IETS) for solid state sensor devices. The advantages of this work over existing concepts include: (1) sensitivity down to the single molecule level, (2) all solid state construction that allows integration into complex hybrid systems, (3) a device design that is conducive to low cost manufacturing, and (4) spectral identification of unknown molecular agents. The research will investigate a novel combination of nanofabrication techniques with atomic layer chemistry to engineer 1-2 nm spaced metal-molecule-metal tunnel junctions that will be doped with model compounds and investigated with IETS for spectral identification. The intellectual merits of the research program are the underlying science of molecular devices, including the understanding of molecule-electrode chemical interactions and charge transport through single molecule devices. In particular, there is a need for experimental data to connect physical properties and electrical measurements in single molecule tunnel junctions. IETS provides a probe of molecular structure in nanofabricated junctions that will advance the science and engineering of molecule-based devices. The broader impacts of the research program are significant for future technologies based on molecular devices that enable low cost, ubiquitous sensors that protect the public from environmental hazards and toxic chemical-biological agents. In addition, the research program will interact with the general public through a multimedia presentation to demonstrate a concrete example of nanotechnology.