Evolutionary history of tuberculosis: An ancient DNA approach
结核病的进化史:古老的 DNA 方法
基本信息
- 批准号:0612222
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-08-01 至 2011-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Tuberculosis (TB) is a re-emerging infectious disease with a global history extending over 3 million years in the Old World and originating in Africa. Recent research in molecular genetics confirms what paleopathologists have long suspected - that Mycobacterium tuberculosis was pathogenic for ancient Americans long before late 15th century European contact. The goal of this project is to analyze DNA from ancient strains of M. tuberculosis in both the New World and Old World to understand their relationship to modern strains, thus addressing questions about the evolutionary history of TB. Specifically, the PIs propose to characterize strains from the earliest Old World skeletal cases of disseminated TB, explore the relationship of these early strains to those found in Britain by Iron Age/Roman times, consider the relationship between Old and New World TB prior to and following the 16th century era of European Exploration, and assess whether the increase in prevalence of tuberculosis during the 17th and 18th centuries in Europe was due to the spread of new strains. The scientific merit of this study is that will expand previous ancient DNA work by focusing on DNA sequences containing informative nucleotide changes that indicate strain/lineage affiliations and relationships. The results will be used to address the hypotheses that prehistoric TB in the Americas was caused by M. tuberculosis strains that are most closely related to modern strains found in Asia and that new strains of M. tuberculosis, most closely related to those prevalent today in Europe, were introduced at European contact. In European samples, the hypothesis that the increase in prevalence of tuberculosis in Europe during the 17th and 18th centuries was due to new strains that were the same as those introduced into the Americas will be tested. In the long term, this project is designed to establish ancient global strain patterning, history of the disease, pattern of virulence, and relationships with other mycobacteria such as M. leprae and M. bovis. This work will focus first upon temporal and geographic coverage, centering upon the spread of the disease through human migration events and characterizing the evolution of M. tuberculosis in relationship to human evolutionary history. The broader impact of this project is that it will provide a unique viewpoint into the evolution of M. tuberculosis and could provide insights valuable to researchers seeking an understanding of the biology of the organism and developing new vaccine strategies. This project will also involve graduate and undergraduate student training in laboratory methods and analyses. Finally, in addition to disseminating results in scholarly articles, we will include information about the project that is accessible to the general public in English and Spanish on the laboratory website (http://www.public.asu.edu/~acstone/lab/molecular_anthropology_lab.htm).
结核病(TB)是一种重新出现的传染病,其全球历史在旧世界延续了300多万年,起源于非洲。最近的分子遗传学研究证实了古病理学家长期以来的怀疑--早在世纪晚期欧洲人接触结核分枝杆菌之前,结核分枝杆菌就对古代美洲人具有致病性。该项目的目标是分析来自古老的M菌株的DNA。新世界和旧世界的结核病,以了解它们与现代菌株的关系,从而解决有关结核病进化史的问题。具体而言,PI建议表征来自最早的旧世界播散性结核病骨骼病例的菌株,探索这些早期菌株与铁器时代/罗马时代在英国发现的菌株的关系,考虑16世纪欧洲探险时代之前和之后旧世界和新世界结核病之间的关系,并评估17和18世纪欧洲结核病流行率的增加是否是由于新菌株的传播。这项研究的科学价值在于,通过关注含有指示菌株/谱系隶属关系和关系的信息核苷酸变化的DNA序列,将扩展以前的古代DNA工作。研究结果将用于解决美洲史前结核病是由M引起的假设。结核菌株,最密切相关的现代菌株在亚洲发现和新菌株的M。结核病,最密切相关的那些今天在欧洲流行,是在欧洲接触介绍。在欧洲样本中,将检验以下假设:17和18世纪欧洲结核病流行率的增加是由于与引入美洲的菌株相同的新菌株。从长远来看,该项目旨在建立古老的全球菌株模式,疾病史,毒力模式以及与其他分枝杆菌如M。leprae和M.牛这项工作将首先集中在时间和地理范围,集中在疾病的传播,通过人类迁移事件和特点的M。结核病与人类进化史的关系这个项目的更广泛的影响是,它将提供一个独特的观点到M的演变。它可以为寻求了解生物体生物学和开发新疫苗策略的研究人员提供有价值的见解。该项目还将涉及对研究生和本科生进行实验室方法和分析方面的培训。最后,除了在学术文章中传播成果外,我们还将在实验室网站(http://www.public.asu.edu/lab/molecular_anthropology_lab.htm)上以英文和西班牙文提供有关该项目的信息,供公众查阅。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anne Stone其他文献
A Comparison of Survival Rates for Treatment of Melanoma Metastatic to the Brain
脑转移性黑色素瘤治疗存活率的比较
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:2.4
- 作者:
Anne Stone;J. Cooper;K. Koenig;J. Golfinos;R. Oratz - 通讯作者:
R. Oratz
An Examination of Organ Donation in the News: A Content Analysis From 2005-2010 of the Barriers to Becoming an Organ Donor
新闻中的器官捐献审视:2005-2010年器官捐献障碍的内容分析
- DOI:
10.5772/32665 - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
B. Quick;Nicole R. LaVoie;Anne Stone - 通讯作者:
Anne Stone
Anne Stone的其他文献
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{{ truncateString('Anne Stone', 18)}}的其他基金
Doctoral Dissertation Research: Ancient Genomics and the Molecular Mechanisms of Human Tolerance to Arsenic
博士论文研究:古代基因组学与人类砷耐受的分子机制
- 批准号:
2142160 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
Doctoral Dissertation Research: The Zoonotic Origins of Tuberculosis Infection in the Pre-contact Americas
博士论文研究:接触前美洲结核病感染的人畜共患起源
- 批准号:
1945812 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Standard Grant
EAGER: Collaborative Research: Proteomic Detection of Amelogenin Proteins for Biological Profiles
EAGER:合作研究:通过蛋白质组学检测牙釉蛋白的生物学特征
- 批准号:
1825055 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
Doctoral Dissertation Improvement Award: DNA Analysis As A Tool For Understanding Population Movement
博士论文改进奖:DNA分析作为理解人口运动的工具
- 批准号:
1622479 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Standard Grant
Ancient American tuberculosis: origin(s), spread, and replacement
古代美国结核病:起源、传播和替代
- 批准号:
1515163 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Continuing Grant
Doctoral Dissertation Improvement: The origins and dispersal of ancient leishmaniasis in the New World: A bioarchaeological and molecular approach
博士论文改进:新大陆古代利什曼病的起源和传播:生物考古学和分子方法
- 批准号:
1232582 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Standard Grant
Doctoral Dissertation Improvement Grant: Primate Interspecific Interactions
博士论文改进补助金:灵长类动物种间相互作用
- 批准号:
1061508 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Standard Grant
An investigation of the evolutionary history of tuberculosis using ancient DNA
利用古代 DNA 研究结核病的进化史
- 批准号:
1063939 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Genetic Adaptation to Disease: Tuberculosis Susceptibility in Native South Americans
博士论文研究:疾病的遗传适应:南美洲原住民的结核病易感性
- 批准号:
0334849 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Standard Grant
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