Acquisition of a Shared Mass Spectrometer for Research, Education, and Training

采购共享质谱仪用于研究、教育和培训

• 批准号: 0619576
• 负责人: Lawrence Scott
• 金额: --
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0619576&HistoricalAwards=false
• 关键词: Acquisition; Shared; Mass; Spectrometer; Research

This award is for the acquisition of a high resolution mass spectrometer with ESI, APCI, APPI, MALDI, MS/MS, and exact-mass capabilities. The instrument will provide much needed analytical support for a broad range of research programs in eight different laboratories. Their research programs are concentrated primarily in the areas of chemical biology, biochemistry, and synthetic organic chemistry and include the followiing: (1) Chemical Tools to Dissect Nonribosomal Peptide Natural Product Biosynthesis, (2) Uncovering the Cellular Interactions of Isoprostanyl Phospholipids, (3) Peptidointercalator Conjugates as Models of Protein and DNA Damage, (4) Sequence-specific Targeting of DNA, (5) Use of Mass Spectrometry in Studying Membrane/Protein Interactions and Archaeal Metabolomes, and (6) Biomimetic Catalysts for Asymmetric Synthesis. The new instrument will enhance the education and training of graduate students, undergraduates, and postdocs. Collectively, the eight research laboratories comprise a group of 84 graduate students, 19 postdocs, and 25 undergraduate research students, the great majority of whom will be users of the requested mass spectrometer on a regular basis. Mass spectrometry experiments will be incorporated into the undergraduate curricula for chemistry and biochemistry majors. To educate and engage as many undergraduate students as possible in the theory and practice of modern mass spectrometry, samples will be run also for students at nearby undergraduate institutions.

该奖项是为了获得具有ESI，APCI，APPI，MALDI，MS/MS和精确质量功能的高分辨率质谱仪。该仪器将为八个不同实验室的广泛研究项目提供急需的分析支持。他们的研究计划主要集中在化学生物学，生物化学和合成有机化学领域，包括以下内容：（1）剖析非核糖体肽天然产物生物合成的化学工具，（2）揭示异前列腺素磷脂的细胞相互作用，（3）作为蛋白质和DNA损伤模型的肽嵌入剂缀合物，（4）DNA的序列特异性靶向，（5）质谱在研究膜/蛋白质相互作用和代谢物组中的应用，（6）用于不对称合成的仿生催化剂。新仪器将加强研究生、本科生和博士后的教育和培训。总的来说，这八个研究实验室包括84名研究生，19名博士后和25名本科生研究生，其中大多数人将定期使用所需的质谱仪。质谱实验将纳入化学和生物化学专业的本科课程。为了在现代质谱的理论和实践中教育和吸引尽可能多的本科生，也将为附近本科院校的学生运行样品。