MRI: Acquisition of a Shared X-ray Diffractometer for Research, Education, and Training

MRI：购买共享 X 射线衍射仪用于研究、教育和培训

• 批准号: 0923264
• 负责人: Lawrence Scott
• 金额: $ 35.04万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923264&HistoricalAwards=false
• 关键词: MRI; Acquisition; Shared; ray; Diffractometer

With this award from the Major Research Instrumentation (MRI) program, Lawrence T. Scott and colleague Amir Hoveyda from Boston College will acquire a single crystal X-ray diffractometer to support research in a variety of areas including: 1) chemical synthesis of uniform, single-chirality carbon nanotubes; 2) design and development of new catalysts for chemical synthesis; 3) biomimetic chemistry relevant to Photosystem II; 4) protein folding in lipid bilayers; 5) identification of new classes of inhibitors of fructose 1,6-bisphosphatase; 6) studies toward the asymmetric synthesis of complex dibenzofuranoids; 7) fused nucleosides (fN) for the synthesis of fDNA; 8) catalytic diboration reactions for use in synthesis; 9) catalytic scaffolding ligands; 10) advancing new chemical methods with X-ray crystallography.The technique of single-crystal X-ray crystallography allows accurate and precise determination of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of molecules relative to the neighboring molecules. These studies will have an impact in a number of areas ranging from synthetic organic and inorganic chemistry to systems of biological interest and materials research. This instrument will be an integral part of teaching as well as research.

来自波士顿学院的劳伦斯·T·斯科特和他的同事阿米尔·霍韦达将获得来自重大研究仪器(MRI)计划的这一奖项，他们将获得一台单晶X射线衍射仪，以支持各种领域的研究，包括：1)均匀、单手性碳纳米管的化学合成；2)化学合成新催化剂的设计和开发；3)与光系统II相关的仿生化学；4)脂质双层中的蛋白质折叠；5)新型果糖1，6-二磷酸酶抑制剂的鉴定；6)复杂二苯并呋喃类化合物的不对称合成研究；7)融合核苷(FN)合成fDNA的研究；8)用于合成的催化二硼反应；9)催化支架配体；10)用X射线结晶学发展新的化学方法。单晶X射线结晶学技术可以准确和精确地确定分子的全部三维结构，包括键的距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这些研究将在许多领域产生影响，从合成有机化学和无机化学到生物系统和材料研究。该仪器将成为教学和研究不可或缺的一部分。