MRI: Development of Synchrotron Based Infrared Microspectroscopy with a Multi-Element Detector

MRI：基于同步加速器的红外显微光谱学与多元素探测器的发展

• 批准号: 0619759
• 负责人: Carol Hirschmugl
• 金额: --
• 依托单位: University of Wisconsin-Milwaukee
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0619759&HistoricalAwards=false
• 关键词: MRI; Development; Synchrotron; Based; Infrared

Technical AbstractUniversity of Wisconsin-Milwaukee will design a mid-infrared (IR) beamline, IRMSI-MED, extracting 400 hor. x 25 vert. mrads2 from a synchrotron bending magnet, that will be developed to homogeneously illuminate a commercial IR microscope equipped with a multi-element detector (MED). This will provide the opportunity to obtain chemical images with diffraction-limited (or better) resolution of 35 mm2 square areas in minutes. Initial research projects include examining kinetics of living cells (phytoplankton), fungi and bacteria-mineral interactions. This project has a potential to impact a wide variety of research areas ranging from soft matter condensed physics, nanoscience, biology, chemistry, veterinary science, engineering, environmental science and geology. This development will impact the research of graduate students, international collaborators from the SESAME program in Jordan, high school students, REU students and participants in the PEOPLE program at the SRC that will be encouraged to use the facility, and there will be workshops designed to educate new users. Lay AbstractFrom the earliest experiments with optical microscopes, researchers have examined the appearance of microbes and other microscopic plants and animals; they have strived to identify the various organelles and sub-cellular structures evident, helping them to infer their biological function. Beyond the visual appearance of these structures, a knowledge of their chemical makeup would provide great insight into how these sub-cellular structures function in a living cell. Moreover, tracking the changes in their chemical makeup would allow scientists to understand the organism's response to changing environmental conditions. The development of a chemically sensitive infrared microscope with multiple, parallel detection channels will greatly expand the ability to examine such biological structures, and to track their changes over minutes. The microscope will be available for users across a wide array of disciplines (e.g. soft matter condensed physics, nanoscience, biology, chemistry, veterinary science, engineering, environmental science and geology), providing a new interdisciplinary tool to the broader scientific community. Many graduate students will be involved in these research efforts. In addition, high school students, REU students and participants in the PEOPLE program will be encouraged to use the facility, and there will be workshops designed to educate new users.

美国威斯康星大学密尔沃基分校将设计一条中红外光束线，IRMSI-MED，提取400小时。x 25垂直mrads 2从同步加速器偏转磁铁，这将被开发为均匀地照亮一个商业红外显微镜配备了多元素检测器（MED）。这将提供在几分钟内获得具有35平方毫米面积的衍射极限（或更好）分辨率的化学图像的机会。 最初的研究项目包括研究活细胞（浮游植物）、真菌和细菌-矿物相互作用的动力学。该项目有可能影响各种各样的研究领域，包括软物质凝聚物理学，纳米科学，生物学，化学，兽医学，工程学，环境科学和地质学。 这一发展将影响研究生的研究，来自约旦的SEENUS项目的国际合作者，高中生，REU学生和SRC的PEOPLE项目参与者，他们将被鼓励使用该设施，并将举办旨在教育新用户的研讨会。 从最早的光学显微镜实验开始，研究人员就研究了微生物和其他微观植物和动物的外观;他们努力识别各种明显的细胞器和亚细胞结构，帮助他们推断其生物功能。 除了这些结构的视觉外观之外，了解它们的化学组成将有助于深入了解这些亚细胞结构在活细胞中的功能。 此外，跟踪它们化学组成的变化将使科学家能够了解生物体对不断变化的环境条件的反应。 具有多个平行检测通道的化学敏感红外显微镜的开发将大大扩展检查此类生物结构的能力，并在几分钟内跟踪其变化。 该显微镜将可供各种学科的用户使用（例如软物质凝聚物理学，纳米科学，生物学，化学，兽医学，工程学，环境科学和地质学），为更广泛的科学界提供新的跨学科工具。 许多研究生将参与这些研究工作。 此外，将鼓励高中生、REU学生和PEOPLE方案的参与者使用该设施，并将举办讲习班，教育新用户。