SGER: Aquatic Nanotoxicology of Nanomaterials and Their Biomolecular Derivatives

0630823KeNanomaterials及其广泛的影响正在迅速重塑我们的科学和技术的景观。这项探索性研究旨在解决了解生物系统和环境中无生命纳米材料的关键需求。三个目标的目的是研究的生物物理相互作用的单壁碳纳米管（SWNTs），一个主要类别的纳米材料，和天然存在的溶血磷脂，并调查脂溶性SWNTs在细胞和整个动物的毒性。这些目标将由具有创造力和生产力记录的研究人员组成的协同团队进行调查，其专业知识涵盖纳米技术，生物物理学，生物学，工程学和环境毒理学领域。

0630823KeNanomaterials and their broad implications are rapidly reshaping the landscape of our science and technology. This proposed exploratory research is to address the crucial need of understanding lifeless nanomaterials in biological systems and in the environment. Three objectives are designed to examine the biophysical interactions of single-walled carbon nanotubes (SWNTs), a major class of nanomaterials, and naturally occurring lysophospholipids, and to investigate the toxicity of lipid-solubilized SWNTs in cells and in whole animals. These objectives will be investigated by a synergetic team of researchers who have track records of creativity and productivity and whose expertise encompasses the fields of nanotechnology, biophysics, biology, engineering, and environmental toxicology.