Conference: 2007 Epigenetics Gordon Research Conference to be held on August 5-10, 2007 in Plymouth, New Hampshire

会议：2007年表观遗传学戈登研究会议将于2007年8月5日至10日在新罕布什尔州普利茅斯举行

• 批准号: 0652490
• 负责人: Steven Jacobsen
• 金额: $ 0.3万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0652490&HistoricalAwards=false
• 关键词: Conference; 2007; Epigenetics; Gordon; Research

The Gordon Research Conference on Epigenetics is the premier venue for presenting new developments in one of the most exciting areas of the biological sciences today. Started in 1995 and now meeting for the seventh time, this conference has earned an international reputation for generating new research avenues as well as fostering progress in the more established areas of epigenetics. The conference has achieved this level of success by consistently providing a unique setting for bringing together a diverse group of scientists, and by cutting across boundaries of organism and methodology, to expand the frontiers of epigenetics research. In 2007 the conference will be co-chaired by mammalian biologist Anne C Ferguson-Smith of University of Cambridge, and plant geneticist Steve Jacobsen at the University of California Los Angeles, both leaders in the field of epigenetics and long time participants of this conference. The study of epigenetics leads to an understanding of genome function. In recent years, epigenetic analysis has revealed some of the most extraordinary forms of gene regulation and quickly become one of the most exciting research areas in genetics and developmental biology. Even as genome projects are providing the complete nucleotide sequence of organism after organism, researchers are turning to the field of epigenetics to understand how that sequence is interpreted in the context of the cell or the organism. Epigenetic modifications such as methylation of the DNA and posttranslational modification of core histones affect the organization and packaging of the chromosome. That these chromosomal marks are both dynamic and heritable leads to epigenetics being one of the most intriguing aspects of biology with a wide range of implications for development, disease and natural variability. It has become clear that epigenetic processes encompass an impressive diversity of mechanisms including RNA-mediated gene regulation, DNA methylation, identification of new pathways in gene control, inheritance of expression states as mediated by RNAs and proteins, cellular and nuclear organization, and response to environmental cues. The richness and versatility of these biological processes has been elucidated through the study of a wide range of diverse organisms and this conference prides itself on its inclusiveness and its respect for the exchange of ideas and value of learning from the full range of model systems.Broad Impacts of the proposed activity: This conference has always placed a strong emphasis on the prominent participation of young investigators, as it is this group that so often defines the leading edge of research efforts. The organizers strive to attract students and postdoctoral fellows to the field and promote the careers of students, postdoctoral fellows, and new principal investigators, by involving them in both the oral and poster presentations. Many established members of the research community consider their first attendance at this meeting to be a career turning point, and it is hoped that similar opportunities are extended to the next generation of young colleagues via this conference. Concerted efforts are being made to support women scientists and to include participants of racial/ethnic backgrounds that are underrepresented in science. The Epigenetics Gordon Conference has a history of supporting women scientists and there are many women principal investigators in this field. For the 2007 conference, ~30% of the confirmed speakers thus far are women. In 2005, 46% of the total attendees were women, and at least this level of overallrepresentation is expected in 2007. This conference serves as an investment in the future of basic and applied research. Perhaps most importantly, it will launch the careers of young scientists in this frontier area.

戈登表观遗传学研究会议是在当今生物科学最激动人心的领域之一展示新发展的主要场所。这次会议始于1995年，目前是第七次开会，在产生新的研究途径以及促进更具成熟的表观遗传学领域的进步方面赢得了国际声誉。会议通过始终提供独特的环境来融合各种各样的科学家，并跨越生物体和方法论的界限来扩大表观遗传学研究的前沿，从而实现了这一成功水平。该会议将由剑桥大学的哺乳动物生物学家安妮·弗格森·史密斯（Anne C Ferguson-Smith）和加利福尼亚大学洛杉矶分校的植物遗传学家史蒂夫·雅各布森（Steve Jacobsen）共同主持，这都是表观遗传学领域和本次会议长期参与者的领导者。对表观遗传学的研究导致对基因组功能的理解。近年来，表观遗传分析揭示了一些最非凡的基因调节形式，并迅速成为遗传学和发育生物学中最令人兴奋的研究领域之一。即使基因组项目在生物体后提供了有机体的完整核苷酸序列，研究人员也正在转向表观遗传学领域，以了解如何在细胞或生物体的背景下解释该序列。表观遗传修饰，例如DNA的甲基化和核心组蛋白的翻译后修饰会影响染色体的组织和包装。这些染色体标记既动态又是可遗传的，这会导致表观遗传学是生物学中最有趣的方面之一，对发育，疾病和自然变异性具有广泛的影响。很明显的是，表观遗传过程包括令人印象深刻的机制多样性，包括RNA介导的基因调节，DNA甲基化，基因控制中新途径的鉴定，由RNA和蛋白质和蛋白质介导的表达状态的遗传，细胞和核组织以及对环境线索的反应。通过研究各种各样的生物体，已经以其包容性及其对拟议活动的全部范围影响的思想和学习价值的尊重而自豪地阐明了这些生物学过程的丰富性和多功能性。这次会议始终强调了这一范围的努力，因此，这是该小组的突出参与，因此，这是该小组的杰出参与，因此，该团队始终是该团队的重要参与。组织者努力吸引学生和博士后研究员进入该领域，并通过使他们参与口头和海报演讲，从而促进学生的职业，博士后研究员和新的主要调查员。研究社区的许多成熟成员认为他们在这次会议上的首次出席是职业转折点，希望通过这次会议将类似的机会扩展到下一代年轻同事。 正在努力支持女性科学家，并包括在科学领域不足的种族/种族背景的参与者。表观遗传学戈登会议有支持女性科学家的历史，并且该领域有许多女性主要研究人员。在2007年会议上，迄今为止约有30％的确认发言人是女性。 2005年，参与者的46％是女性，至少在2007年预计这一水平的总体表现水平。这次会议是对基础和应用研究的未来的投资。也许最重要的是，它将在这个边境地区启动年轻科学家的职业。