A Miniature Implantable Device for Continuous Glucose Monitoring

用于连续血糖监测的微型植入装置

• 批准号: 0702101
• 负责人: Qiao Lin
• 金额: $ 20.4万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0702101&HistoricalAwards=false
• 关键词: Miniature; Implantable; Device; Continuous; Glucose

Integrative, Hybrid and Complex SystemsQiao Lin, Department of Mechanical Engineering, Columbia UniversityQian Wang, University of South CarolinaA Miniature Implantable Device for Continuous Glucose MonitoringIntellectual Merit: This project investigates a miniature, subcutaneously implantable sensor system with the potential to allow long-term continuous monitoring of glucose in interstitial fluid. Enabled by micro electro-mechanical systems (MEMS) technology, the device will exploit viscometric measurements of non-consumptive, reversible equilibrium binding (i.e., affinity binding) of glucose to a glucose-specific polymer. The device consists of a vibrating element sealed in a micro-chamber by a semipermeable membrane. A solution of a polysaccharide, crosslinked by the glucose-specific polymer, fills the micro-chamber. Glucose permeates from subcutaneous tissue into the chamber through the membrane and competitively binds to the polymer, causing reversible de-crosslinking of the polysaccharide. The resulting changes in solution viscosity are obtained via vibration measurements, thereby determining the glucose concentration. Measurement data transmission can be achieved by wireless circuitry.Broader Impact: Currently, approximately 20.8 million people in the United States have diabetes. It has been demonstrated that close monitoring of daily blood glucose levels reduces the risk of diabetes-related complications. This can be accomplished by continuous glucose monitoring (CGM), which is the intended use of the miniature affinity sensor to be developed in this research. Compared with other CGM approaches, the device under investigation utilizes equilibrium binding and does not involve consumption of glucose. This implies that, when implanted, the device can be more tolerant to retardation of glucose transport resulting from fouling by biological agents. This allows stable, long-term continuous glucose monitoring. With the affinity sensing principle extendable to other chemical substances of analytical interest, the device is useful for the care of diabetes and potentially other diseases, as well as applications such as metabolic monitoring in the battlefield, bioterrorism threat detection, and environmental toxin monitoring. The research is integrated with graduate and undergraduate education and involves active educational outreach activities in the New York, NY and Columbia, SC, areas.

集成、混合和复杂系统乔琳，哥伦比亚大学机械工程系王倩，南卡罗来纳大学一种用于连续葡萄糖监测的微型植入式装置智力优势：该项目研究了一种微型皮下植入式传感器系统，具有长期连续监测组织液中葡萄糖的潜力。 通过微机电系统（MEMS）技术，该装置将利用非消耗性、可逆平衡结合（即，亲和结合）。 该装置包括一个振动元件密封在一个微室的半透膜。 由葡萄糖特异性聚合物交联的多糖溶液填充微室。 葡萄糖通过膜从皮下组织渗透到腔室中，并竞争性地结合到聚合物上，引起多糖的可逆去交联。 通过振动测量获得溶液粘度的变化，从而确定葡萄糖浓度。测量数据传输可以通过无线电路实现。更广泛的影响：目前，美国约有2080万人患有糖尿病。 已经证明，密切监测每日血糖水平可以降低糖尿病相关并发症的风险。 这可以通过连续葡萄糖监测（CGM）来实现，这是本研究中开发的微型亲和传感器的预期用途。 与其他CGM方法相比，研究中的器械利用平衡结合，不涉及葡萄糖消耗。 这意味着，当植入时，该装置可以更耐受由生物制剂污染引起的葡萄糖转运延迟。 这允许稳定、长期的连续葡萄糖监测。 由于亲和传感原理可扩展到其他化学物质的分析兴趣，该设备是有用的糖尿病和潜在的其他疾病的护理，以及应用，如代谢监测在战场上，生物恐怖主义威胁检测，和环境毒素监测。 该研究与研究生和本科生教育相结合，并涉及在纽约，纽约州和哥伦比亚，SC地区积极的教育推广活动。