Theory of Gene Trees and Species Trees

基因树和物种树理论

• 批准号: 0716904
• 负责人: Noah Rosenberg
• 金额: $ 44.2万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0716904&HistoricalAwards=false
• 关键词: Theory; Gene; Trees; Species

This project will develop computational methods for understanding the relationships of gene sequences from closely related species. The goal is to determine the extent to which the histories of individual genes reflect the descent history of species, and to devise methods for inferring relationships of closely related species from sequences of multiple genes. A mathematical theory will be developed that describes how the sequence patterns of a gene in different species reflect or fail to reflect the species relationships. The frequency of occurrence of a particularly extreme form of gene tree/species tree discordance - in which the most probable genetic pattern in a set of species does not match the species tree shape - will be studied using computation and simulation, and an understanding of this extreme discordance will be incorporated into novel algorithms for inferring species trees.Trees describing the relationships between species are the basic structures on which the diversity of life can be understood, and they are an essential component of many areas of biology. The results and methods produced by this project will produce shared software that can be used for improved inference of species relationships from genetic data.

这个项目将开发计算方法，以了解来自密切相关物种的基因序列之间的关系。其目标是确定单个基因的历史在多大程度上反映了物种的后代历史，并设计出从多个基因序列推断密切相关物种关系的方法。将开发一种数学理论，描述不同物种中的基因序列模式如何反映或未能反映物种之间的关系。一种特别极端的基因树/物种树不一致性的出现频率--一组物种中最可能的遗传模式与物种树的形状不匹配--将通过计算和模拟来研究，对这种极端不一致性的理解将被纳入推断物种树的新算法中。描述物种之间关系的树是可以理解生命多样性的基本结构，它们是许多生物学领域的重要组成部分。该项目产生的结果和方法将产生可用于改进从遗传数据推断物种关系的共享软件。