MRI: Acquisition of an EPR Spectrometer

有了这项来自主要研究仪器计划（MRI）的奖励，犹他州州立大学的化学和生物化学系将获得一台没有磁铁和电源的EPR光谱仪。该仪器将用于多个研究项目，包括（1）固氮酶的机理研究，（2）脂肪族环氧化物和酮羧化关键酶中金属中心和CoM结合决定簇的表征，（3）谷胱甘肽酶II活性中心双核金属中心的模型配合物，（4）白内障超声乳化术中自由基的形成。电子顺磁共振（EPR）光谱仪可提供分子和分子电子结构的信息。它还可以用于获得有关自由基寿命的信息，自由基是通常对肿瘤生长和/或各种化学反应的起始至关重要的短寿命物质。这些研究将产生有价值的信息，即生物系统中反应性的化学基础

With this award from the Major Research Instrumentation program (MRI), the Department of Chemistry and Biochemistry at Utah State University will acquire an EPR spectrometer without the magnet and power supply. This instrument will be used in several research projects including (1) mechanistic studies of nitrogenase, (2) characterization of metal centers and CoM binding determinant in key enzymes of aliphatic epoxide and ketone carboxylation, (3) model complexes for active site binuclear metal centers in glyoxalase II enzymes, and (4) free radical formation during cataract phacoemulsification.An electron paramagnetic resonance (EPR) spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will yield valuable information the chemical basis of reactivity in biological systems