MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutants

提案：0722861 PI：Michael S Milligan机构：SUNY College at Fredonia（纽约州立大学弗雷多尼亚分校）MRI：购置气相色谱仪用于研究 分析新的和正在出现的化学品的高级培训 关注和遗留污染物这项工作增强了两个主要本科院校，纽约州立大学（SUNY）弗雷多尼亚分校和纽约州立大学奥斯韦戈分校的跨校园合作。纽约州立大学弗雷多尼亚分校的首席研究员（迈克尔·S。Milligan，化学和生物化学系）和纽约州立大学奥斯韦戈的联合首席研究员（James J. Pagano，化学系和环境研究中心）在过去十年中成功地在许多资助和非资助的研究项目中合作，这些项目导致了许多学生合著的出版物和会议摘要。PI和Co-PI都负责监督现代分析实验室，致力于样品提取，清洁和有机污染物分析。通过购置三台气相色谱仪：一个具有更新和现代化的质量选择性检测（包括电子碰撞、正离子化学电离和负离子化学电离源）和两个具有电子捕获检测能力的PI和Co-PI将进一步提高他们在分析新的和正在出现的关注化合物方面的专业知识，内分泌系统干扰化合物，如氯代二恶英/呋喃（PCDD/Fs）和共面多氯联苯（PCB），以及遗留污染物，如多氯联苯、多溴二苯醚（PBDEs）和大气样本中发现的有机氯农药，五大湖鱼类，其他环境媒介。该项目的智力价值涉及用于检测和定量有机污染物的痕量分析技术的开发、进步和改进。这些类型的分析挑战通常需要亚皮克和十亿分之一（ppb）的检测限，并需要复杂的仪器才能成功。PI和Co-PI在分析上述有机物种方面都有超过17年的经验，并且有资格推动这一领域的发现。这些化合物已被指定为持久性生物累积毒物（PBT），并被认为具有对人类和其他动物物种有重大影响的毒理学特性。这些PBT中的许多被假设为内分泌系统干扰化合物，其模拟内分泌系统的作用可以在低得令人震惊的浓度下表现出来。环境中可能存在其他持久性苯并三唑，但尚未查明。因此，开发和完善现代分析技术，以检测、鉴定和测量这些目标化合物在空气和鱼组织等介质中的浓度具有重要意义。本项目的广泛影响将有助于促进基础研究和发现，跨校园合作，改善实验室技术，大学生教育和培养有抱负的科学家。本科和硕士水平的研究生将获得宝贵的现场，实验室，分析和解释经验，同时在PI和Co-PI的监督下工作，导致在工业，政府实验室和研究生院的研究生职位。这些学生将接触到国家的最先进的分析技术所需的痕量分析程序，他们将采取的技能和经验教训，从这些经验与他们在他们的职业生涯中前进。学生将在科学会议上准备和展示结果。PI和Co-PI的实验室设施的改善将在未来几年吸引许多潜在的学生，并使这些实验室在追求校外资金方面保持竞争力。

Proposal: 0722861PI: Michael S MilliganInstitution: SUNY College at FredoniaTitle: MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutantsThis work augments a cross-campus collaboration at two primarily undergraduate institutions, the State University of New York (SUNY) at Fredonia and SUNY at Oswego. The Principal Investigator at SUNY Fredonia (Michael S. Milligan, Department of Chemistry and Biochemistry) and the Co-Principal Investigator at SUNY Oswego (James J. Pagano, Department of Chemistry and the Environmental Research Center) have successfully collaborated in numerous funded and non-funded research projects over the past ten years that have led to many student co-authored publications and conference abstracts. Both the PI and the Co-PI supervise modern analytical laboratories dedicated to sample extraction, clean-up, and analysis of organic contaminants. Through the acquisition of three gas chromatographs: one with updated and modernized mass selective detection (including electron impact, positive ion chemical ionization, and negative ion chemical ionization sources) and two with electron capture detection capabilities, the PI and Co-PI will further enhance their expertise in the analysis of new and emerging chemical compounds of concern, endocrine system disrupting compounds such as chlorinated dioxins/furans (PCDD/Fs) and co-planar polychlorinated biphenyls (PCBs), and legacy pollutants such as PCBs, polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides found in atmospheric samples, Great Lakes fish, and other environmental media. The intellectual merit of this project involves the development, advancement, and refinement of trace analytical techniques used for the detection and quantification of organic contaminants. These types of analytical challenges often demand sub-picogram and sub-part per billion (ppb) detection limits, and require sophisticated instrumentation for success. The PI and Co-PI each have over seventeen years of experience in the analysis of the organic species listed above, and are well qualified to advance this field of discovery. These chemical compounds have been designated as persistent bioaccumulative toxics (PBTs), and are believed to possess toxicological properties that are of significant concern to humans and other animal species. Many of these PBTs are hypothesized to be endocrine system disrupting compounds, whose hormonemimicking effects can be manifested at alarmingly low concentrations. Other PBTs are likely present in the environment, but have yet to be identified. Accordingly, developing and perfecting modern analytical techniques to detect, identify, and measure the concentrations of these target compounds at such demanding levels in media such as air and fish tissue is of great importance.The broader impacts of this project will serve to promote fundamental research and discovery, cross-campus collaborations, improvement of laboratory technology, education of university students, and training of aspiring scientists. Undergraduate and master's level research students will gain valuable field, laboratory, analytical, and interpretive experience while working under the supervision of the PI and Co-PI, leading to post-graduate positions in industry, governmental laboratories, and graduate school. These students will be exposed to state-of-the-art analytical techniques required for trace analytical procedures, and they will take the skills and lessons learned from these experiences with them as they advance in their careers. Students will prepare and present results at scientific conferences. Improved laboratory facilities for the PI and Co-PI will attract many prospective students for the future years, and allow these laboratories to remain competitive in pursuits for extramural funding.