MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutants
MRI:采购气相色谱仪器,用于分析新的和新兴的令人关注的化学品和遗留污染物的研究和高级培训
基本信息
- 批准号:0722861
- 负责人:
- 金额:$ 15.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-08-15 至 2009-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Proposal: 0722861PI: Michael S MilliganInstitution: SUNY College at FredoniaTitle: MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutantsThis work augments a cross-campus collaboration at two primarily undergraduate institutions, the State University of New York (SUNY) at Fredonia and SUNY at Oswego. The Principal Investigator at SUNY Fredonia (Michael S. Milligan, Department of Chemistry and Biochemistry) and the Co-Principal Investigator at SUNY Oswego (James J. Pagano, Department of Chemistry and the Environmental Research Center) have successfully collaborated in numerous funded and non-funded research projects over the past ten years that have led to many student co-authored publications and conference abstracts. Both the PI and the Co-PI supervise modern analytical laboratories dedicated to sample extraction, clean-up, and analysis of organic contaminants. Through the acquisition of three gas chromatographs: one with updated and modernized mass selective detection (including electron impact, positive ion chemical ionization, and negative ion chemical ionization sources) and two with electron capture detection capabilities, the PI and Co-PI will further enhance their expertise in the analysis of new and emerging chemical compounds of concern, endocrine system disrupting compounds such as chlorinated dioxins/furans (PCDD/Fs) and co-planar polychlorinated biphenyls (PCBs), and legacy pollutants such as PCBs, polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides found in atmospheric samples, Great Lakes fish, and other environmental media. The intellectual merit of this project involves the development, advancement, and refinement of trace analytical techniques used for the detection and quantification of organic contaminants. These types of analytical challenges often demand sub-picogram and sub-part per billion (ppb) detection limits, and require sophisticated instrumentation for success. The PI and Co-PI each have over seventeen years of experience in the analysis of the organic species listed above, and are well qualified to advance this field of discovery. These chemical compounds have been designated as persistent bioaccumulative toxics (PBTs), and are believed to possess toxicological properties that are of significant concern to humans and other animal species. Many of these PBTs are hypothesized to be endocrine system disrupting compounds, whose hormonemimicking effects can be manifested at alarmingly low concentrations. Other PBTs are likely present in the environment, but have yet to be identified. Accordingly, developing and perfecting modern analytical techniques to detect, identify, and measure the concentrations of these target compounds at such demanding levels in media such as air and fish tissue is of great importance.The broader impacts of this project will serve to promote fundamental research and discovery, cross-campus collaborations, improvement of laboratory technology, education of university students, and training of aspiring scientists. Undergraduate and master's level research students will gain valuable field, laboratory, analytical, and interpretive experience while working under the supervision of the PI and Co-PI, leading to post-graduate positions in industry, governmental laboratories, and graduate school. These students will be exposed to state-of-the-art analytical techniques required for trace analytical procedures, and they will take the skills and lessons learned from these experiences with them as they advance in their careers. Students will prepare and present results at scientific conferences. Improved laboratory facilities for the PI and Co-PI will attract many prospective students for the future years, and allow these laboratories to remain competitive in pursuits for extramural funding.
建议:0722861PI:迈克尔·S·米利根机构:弗里多尼亚的纽约州立大学标题:核磁共振成像:购买气相色谱仪器,用于研究和高级培训新出现的令人关注的化学品和遗留污染物的分析这项工作加强了两个主要本科机构的跨校园合作,分别是弗雷多尼亚的纽约州立大学(SUNY)和奥斯威戈的纽约州立大学。纽约州立大学弗雷多尼亚分校的首席研究员(迈克尔·米利根,化学和生物化学系)和纽约州立大学奥斯威戈分校的联合首席研究员(詹姆斯·J·帕加诺,化学系和环境研究中心)在过去十年中成功地在许多有资助和无资助的研究项目中进行了合作,这些项目导致了许多学生共同撰写的出版物和会议摘要。PI和Co-PI都监督致力于样品提取、清理和有机污染物分析的现代分析实验室。通过购置三台气相色谱仪:一台具有最新和现代化的质量选择检测(包括电子撞击、正离子化学电离源和负离子化学电离源),两台具有电子捕获检测能力,PI和Co-PI将进一步增强其在分析新出现的令人关注的化合物、内分泌干扰化合物,如氯化二恶英/呋喃(PCDD/Fs)和共面多氯联苯(PCBS),以及遗留污染物,如多氯联苯、多溴二苯醚(PBDEs),以及大气样品、五大湖鱼类和其他环境介质中发现的有机氯农药方面的专业知识。该项目的智力价值包括用于检测和量化有机污染物的痕量分析技术的开发、进步和改进。这些类型的分析挑战通常需要亚皮卡和十亿分之一(Ppb)的检测极限,并需要复杂的仪器才能成功。PI和Co-PI在分析上述有机物种方面都有超过17年的经验,完全有资格推动这一发现领域的发展。这些化合物被指定为持久性生物累积毒素(PBT),并被认为具有人类和其他动物物种非常关注的毒理学特性。其中许多PBT被假设为内分泌系统干扰物,其激素刺激作用可以在令人震惊的低浓度下表现出来。其他多溴联苯很可能存在于环境中,但尚未确定。因此,发展和完善现代分析技术,在空气和鱼类组织等介质中检测、鉴定和测量这些目标化合物的浓度具有重要意义。该项目的更广泛影响将有助于促进基础研究和发现、跨校园合作、实验室技术改进、大学生教育和有志于成为科学家的培养。本科生和硕士研究生将在PI和Co-PI的指导下获得宝贵的现场、实验室、分析和解释经验,从而在工业、政府实验室和研究生院获得研究生职位。这些学生将接触到痕量分析程序所需的最先进的分析技术,随着他们的职业生涯的发展,他们将从这些经验中获得技能和经验教训。学生们将在科学会议上准备和展示研究成果。改进的PI和Co-PI实验室设施将在未来几年吸引许多潜在的学生,并使这些实验室在争取校外资金方面保持竞争力。
项目成果
期刊论文数量(0)
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Michael Milligan其他文献
Comparing Open Ondemand and Jupyterhub as Interactive HPC Gateways
比较 Open Ondemand 和 Jupyterhub 作为交互式 HPC 网关
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Michael Milligan;Graham T. Allan;Nicholas J. H. Dunn;Mathew Mix - 通讯作者:
Mathew Mix
The Resident Room
- DOI:
10.1016/j.prro.2021.02.008 - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Subha Perni;Anurag Saraf;Michael Milligan - 通讯作者:
Michael Milligan
Teaching Mentoring: Utilizing a Resident-Student Peer Mentorship Program as a Tool to Educate Residents About the Core Components of Mentoring
- DOI:
10.1016/j.ijrobp.2021.05.152 - 发表时间:
2021-09-01 - 期刊:
- 影响因子:
- 作者:
Anurag Saraf;Matthew Gallitto;Idalid Franco;Michael Milligan;Subha Perni;Dalia Larios;Graham Boyd;Cheng-Chia Wu;Rachel Jimenez - 通讯作者:
Rachel Jimenez
Studies of mobile phone use and brain tumor risk are independent of industry influence.
对手机使用和脑肿瘤风险的研究独立于行业影响。
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:45.3
- 作者:
J. Rowley;Michael Milligan - 通讯作者:
Michael Milligan
Semisynthetic model calibration for monitoring glucose in mammalian cell culture with in situ near infrared spectroscopy
利用原位近红外光谱监测哺乳动物细胞培养物中葡萄糖的半合成模型校准
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:3.8
- 作者:
Michael Milligan;N. Lewin‐Koh;Daniel Coleman;A. Arroyo;V. Saucedo - 通讯作者:
V. Saucedo
Michael Milligan的其他文献
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{{ truncateString('Michael Milligan', 18)}}的其他基金
Gas Chromatography/Mass Spectrometry in Undergraduate Chemistry and Science
本科化学与科学中的气相色谱/质谱分析
- 批准号:
9551319 - 财政年份:1995
- 资助金额:
$ 15.69万 - 项目类别:
Standard Grant
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