MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutants

提案：0722861PI: Michael S milligan机构：纽约州立大学弗里多尼亚分校标题：核磁共振成像：气相色谱仪器的收购，用于研究和先进的培训，分析新的和新兴的化学关注和遗留污染物。这项工作增加了两个主要的本科机构，纽约州立大学弗里多尼亚分校和纽约州立大学奥斯威戈分校的跨校园合作。在过去的十年里，纽约州立大学Fredonia分校的首席研究员（Michael S. Milligan，化学和生物化学系）和纽约州立大学Oswego分校的联合首席研究员（James J. Pagano，化学系和环境研究中心）在许多资助和非资助的研究项目中成功合作，并发表了许多学生合著的出版物和会议摘要。PI和Co-PI监督致力于样品提取，清理和有机污染物分析的现代分析实验室。通过收购三台气相色谱仪：一个具有更新和现代化的大规模选择性检测（包括电子影响，正离子化学电离和负离子化学电离源），两个具有电子捕获检测能力，PI和Co-PI将进一步加强他们在分析新的和新兴的化合物方面的专业知识，如氯化二恶英/呋喃（PCDD/Fs）和共面多氯联苯（PCBs）等内分泌系统干扰化合物。以及遗留污染物，如多氯联苯、多溴联苯醚（PBDEs）和在大气样本、五大湖鱼类和其他环境介质中发现的有机氯农药。该项目的智力价值涉及用于检测和定量有机污染物的痕量分析技术的发展、进步和改进。这些类型的分析挑战通常需要亚图和十亿分之一（ppb）的检测限，并且需要复杂的仪器才能成功。PI和Co-PI在上述有机物种的分析方面都有超过17年的经验，并且很有资格推进这一领域的发现。这些化合物已被指定为持久性生物蓄积性毒物（pbt），并被认为具有对人类和其他动物物种具有重大影响的毒理学特性。许多这些pbt被假设为内分泌系统干扰化合物，其激素模拟效应可以在低浓度下表现出来。环境中可能也存在其他pbt，但尚未确定。因此，发展和完善现代分析技术来检测、鉴定和测量这些目标化合物在空气和鱼组织等介质中如此高水平的浓度是非常重要的。这项计划的广泛影响将有助于促进基础研究和发现、跨校园合作、改进实验室技术、教育大学生和培养有抱负的科学家。本科和硕士水平的研究学生将在PI和Co-PI的监督下工作，获得宝贵的现场，实验室，分析和解释经验，从而在工业，政府实验室和研究生院获得研究生职位。这些学生将接触到痕量分析过程所需的最先进的分析技术，他们将从这些经验中吸取技能和教训，并在他们的职业生涯中取得进步。学生将准备并在科学会议上展示结果。为PI和Co-PI改进的实验室设施将在未来几年吸引许多潜在的学生，并使这些实验室在争取校外资助时保持竞争力。

Proposal: 0722861PI: Michael S MilliganInstitution: SUNY College at FredoniaTitle: MRI: Acquisition of gas chromatographic instrumentation for research and advanced training in the analysis of new and emerging chemicals of concern and legacy pollutantsThis work augments a cross-campus collaboration at two primarily undergraduate institutions, the State University of New York (SUNY) at Fredonia and SUNY at Oswego. The Principal Investigator at SUNY Fredonia (Michael S. Milligan, Department of Chemistry and Biochemistry) and the Co-Principal Investigator at SUNY Oswego (James J. Pagano, Department of Chemistry and the Environmental Research Center) have successfully collaborated in numerous funded and non-funded research projects over the past ten years that have led to many student co-authored publications and conference abstracts. Both the PI and the Co-PI supervise modern analytical laboratories dedicated to sample extraction, clean-up, and analysis of organic contaminants. Through the acquisition of three gas chromatographs: one with updated and modernized mass selective detection (including electron impact, positive ion chemical ionization, and negative ion chemical ionization sources) and two with electron capture detection capabilities, the PI and Co-PI will further enhance their expertise in the analysis of new and emerging chemical compounds of concern, endocrine system disrupting compounds such as chlorinated dioxins/furans (PCDD/Fs) and co-planar polychlorinated biphenyls (PCBs), and legacy pollutants such as PCBs, polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides found in atmospheric samples, Great Lakes fish, and other environmental media. The intellectual merit of this project involves the development, advancement, and refinement of trace analytical techniques used for the detection and quantification of organic contaminants. These types of analytical challenges often demand sub-picogram and sub-part per billion (ppb) detection limits, and require sophisticated instrumentation for success. The PI and Co-PI each have over seventeen years of experience in the analysis of the organic species listed above, and are well qualified to advance this field of discovery. These chemical compounds have been designated as persistent bioaccumulative toxics (PBTs), and are believed to possess toxicological properties that are of significant concern to humans and other animal species. Many of these PBTs are hypothesized to be endocrine system disrupting compounds, whose hormonemimicking effects can be manifested at alarmingly low concentrations. Other PBTs are likely present in the environment, but have yet to be identified. Accordingly, developing and perfecting modern analytical techniques to detect, identify, and measure the concentrations of these target compounds at such demanding levels in media such as air and fish tissue is of great importance.The broader impacts of this project will serve to promote fundamental research and discovery, cross-campus collaborations, improvement of laboratory technology, education of university students, and training of aspiring scientists. Undergraduate and master's level research students will gain valuable field, laboratory, analytical, and interpretive experience while working under the supervision of the PI and Co-PI, leading to post-graduate positions in industry, governmental laboratories, and graduate school. These students will be exposed to state-of-the-art analytical techniques required for trace analytical procedures, and they will take the skills and lessons learned from these experiences with them as they advance in their careers. Students will prepare and present results at scientific conferences. Improved laboratory facilities for the PI and Co-PI will attract many prospective students for the future years, and allow these laboratories to remain competitive in pursuits for extramural funding.