Collaborative Research: An Arabidopsis Polymorphism Database

合作研究：拟南芥多态性数据库

• 批准号: 0723860
• 负责人: Brandon Gaut
• 金额: $ 48.63万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723860&HistoricalAwards=false
• 关键词: Collaborative; Research; Arabidopsis; Polymorphism; Database

Abstract This project will to generate a community resource for Arabidopsis genetics by integrating several new data sets with the existing A. thaliana genome sequence and those of two closely related species, A. lyrata and Capsella rubella. These data will make it possible to answer fundamental questions about the evolution of A. thaliana, and will facilitate the interpretation of the existing genome sequence. It is analogous to similar efforts to understand human variation and evolution by integrating vast amounts of human polymorphism data with genome sequences from closely related primates like chimpanzee and orangutan. This project will provide a tool for making sense of genetic variation. Understanding how genotypic variation translates into phenotypic variation and how it is structured in populations is fundamental to our understanding of evolution, and has enormous practical implications for human health as well as for plant and animal breeding. The project will also provide training opportunities in bioinformatics and computational biology for multiple students at different levels, areas where there is a nationally recognized shortage of biology students with the requisite quantitative skills.

摘要本计画将整合数个新资料集与现有的拟南芥基因组资料库，以建立一个拟南芥基因组的社群资源。thaliana基因组序列和两个近缘种A. lyrata和荠菜（Capsella rubella）。这些数据将使我们有可能回答有关A. thaliana，并将有助于解释现有的基因组序列。这类似于通过整合大量的人类多态性数据与密切相关的灵长类动物（如黑猩猩和猩猩）的基因组序列来了解人类变异和进化的类似努力。这个项目将提供一个工具，使遗传变异的意义。了解基因型变异如何转化为表型变异以及它在种群中的结构是我们理解进化的基础，对人类健康以及植物和动物育种具有巨大的实际意义。该项目还将为不同级别的多名学生提供生物信息学和计算生物学方面的培训机会，在这些领域，全国公认缺乏具备必要定量技能的生物学学生。