En-Gen: Ecological Genomics of Drought Adaptation in Mimulus

En-Gen：酸浆菌干旱适应的生态基因组学

• 批准号: 0723814
• 负责人: John Willis
• 金额: $ 86.68万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723814&HistoricalAwards=false
• 关键词: En; Gen; Ecological; Genomics; Drought

Understanding adaptive plant responses to aridity is key for predicting evolutionary responses to climate change. The proposed research integrates ecology, physiology, and genomics to identify the mechanisms that allow plants to adapt to water availability and drought stress. Using the emerging model species Mimulus guttatus (monkeyflower), the investigators will search for genes involved in drought escape (flowering time) and dehydration avoidance (water use efficiency). With ecological experiments in the wild, this work will link natural genomic variation to functional ecological adaptations. The investigators will also characterize natural drought response variation among genotypes collected from diverse habitats, and generate genetic lines that can be used to identify novel genomic regions responsible for adaptation to water availability. By addressing fundamental questions about plant adaptation to water availability, the research will greatly deepen our understanding of environmental genomics. To facilitate rapid future studies, the highly diverse genetic material generated by this project will be made available to the entire scientific community. Students and postdoctoral fellows will receive cross-disciplinary mentoring and training, to prepare them for collaborative studies at levels from the landscape to the nucleotide. The investigators will engage high school and undergraduate students from underrepresented groups in workshops and research projects.

了解自适应植物对干旱的反应是预测气候变化进化反应的关键。拟议的研究将生态学，生理学和基因组学整合，以确定允许植物适应水的可用性和干旱压力的机制。使用新兴模型物种Mimulus Guttatus（Monkeyflower），研究人员将搜索参与干旱逃生（开花时间）和避免脱水（用水效率）的基因。通过野外生态实验，这项工作将自然基因组变异与功能生态适应联系起来。研究人员还将表征从不同栖息地收集的基因型之间的自然干旱反应差异，并产生遗传线，可用于识别负责适应水的新型基因组区域。通过解决有关植物适应水利用率的基本问题，该研究将大大加深我们对环境基因组学的理解。为了促进未来的快速研究，该项目产生的高度多样化的遗传物质将提供给整个科学界。学生和博士后研究员将接受跨学科的指导和培训，以准备从景观到核苷酸的水平进行协作研究。调查人员将在研讨会和研究项目中吸引来自代表性不足的团体的高中和本科生。