EXP-SA: Receptor-Free Detection of Explosives

摘要：目的：本提案的目的是开发一种独特的多模态检测方案，该方案由基于mosfet嵌入微悬臂梁和原位MEMS加热器的创新电子信号转导方法锚定。智力优势：我们建议开发一种无受体检测方法，用于化学传感和识别爆炸物，通过利用它们的区别热响应，结合全电子MOSFET信号检测，所有这些都适用于大规模并行和多路检测模式，并且具有传感器对爆炸蒸汽响应的必要正交性。具体而言，我们计划解决以下智力挑战：1)设计和制造嵌入mosfet的微悬臂传感器，该传感器可以提供前所未有的气体/蒸汽纳米机械检测灵敏度。2)设计和制造可在50-100毫秒内以编程方式均匀加热的MOSFET悬臂梁。3)具有高选择性的炸药组分热形态论证，使其能够区分炸药中相关的蒸气种类。4)样品收集和快速预浓缩装置的设计，10秒内收集炸药，10秒内再生系统。5)在有干扰物存在的情况下对爆炸物和混合物的探测演示。再加上用于全电子信号转导和检测方法的mosfet嵌入式微悬臂，我们相信我们的组合方法为高选择性检测爆炸物提供了独特且开箱外的主动性。更广泛的影响：拟议的传感器系统主题将被纳入传感器模块，作为NU材料世界网络（MWN）计划的一部分，该计划将覆盖数千名高中生和数百名教师，包括国防部机构。我们将利用NCLT（教师）、NSEC （reu）和MRC （MIN）下的其他北大外展项目，吸引代表性不足的学生进行研究实习和研究生支持。拟议的团队将参与当地代表性不足的学生工程社团。我们将在ASME教程模块中纳入研究主题。西北大学正在与芝加哥科学工业博物馆（CMSI）的巴里·阿普里森博士团队合作举办纳米技术展览。我们的团队将为CMSI纳米技术展览的发展提供建议和意见，包括生物化学传感器的主题。总的来说，我们将帮助实现研究与大学和研究生教育、实践培训、专业发展和更广泛的社会影响的有效整合。

ABSTRACTObjective:The objective of this proposal is to develop a unique combination of multimodal detection scheme anchored by an innovative electronic signal transduction approach based on MOSFET-embedded microcantilevers coupled with in-situ MEMS heaters.Intellectual Merit: We propose to develop a receptor-free detection approach for chemical sensing and identifying explosives by exploiting their discriminating thermal response, in combination with an all-electronic MOSFET signal detection all of which are amenable to massively parallel and multiplexed mode for detection and with requisite orthogonality of sensor response to explosive vapors. Specifically, we plan to address the following intellectual challenges:1) Design and fabrication of MOSFET-embedded microcantilever sensors that can provide unprecedented sensitivity of nanomechanical detection of gases/vapors.2) Design and fabrication of MOSFET cantilevers that can be heated uniformly in a programmed manner within 50-100 milliseconds.3) Demonstration of thermal speciation of explosive components with high selectivity, to enable discrimination of relevant vapor species in explosives.4) Design of sample collection and fast preconcentrator units that can collect explosives within 10 seconds and regenerate the system within 10 seconds.5) Demonstration of detection of explosives and mixtures in the presence of interferents. Coupled with MOSFET-embedded microcantilevers for all-electronic signal transduction and detection approach, we believe that our combined approach provides for a unique and out-of-the-box initiative for highly selective detection of explosives.Broader Impact: The proposed sensor system theme will be incorporated in a sensor module as a part of Materials World Network (MWN) program at NU, which reaches thousands of high school students and hundreds of teachers, including DOD establishments. We will leverage other NU outreach programs under NCLT (teachers), NSEC (REUs) and MRC (MIN) to attract underrepresented students for research internship and graduate support. The proposed team will engage in local underrepresented student engineering societies. We will incorporate research themes in the ASME tutorial modules. Northwestern is involved in an ongoing collaboration with Dr. Barry Aprison team at the Chicago Museum of Science & Industry (CMSI) for a nanotechnology exhibit. Our team will help provide advice and input in the development of Nanotechnology exhibit at CMSI, including a theme on biochemical sensors. Collectively, we will help achieve effective integration of research with UG and graduate education, hands-on training, professional development and broader societal impact.