MOSFET-embedded Microcantilever-based Multiplexed Sensor Platform for Continuous Physiological Monitoring of Biomolecular Interactions

具有所需灵敏度、特异性和工程约束的生物分子种类的感测对于许多领域是至关重要的;范围从有毒种类的环境监测到个性化健康诊断。这种可行的传感器系统的多样性和多重考虑需要跨学科的方法，该方法结合了生物结合事件的先天特异性、可广泛部署的信号转导平台以及必要的经济、人体工程学和系统级约束。鉴于这种需要多样化和多方面的方法，国际合作是必不可少的，以推进我们的理解多路复用集成传感器阵列的生化传感。生物工程传感器研究需要大量的设备工程模拟，过程迭代和高水平的实验室实验，其中西北大学（NU）和巴塞尔大学（UB）拥有大量的互补资源和专业知识。这个OISE合作项目将汇集美国和瑞士的研究人员，以解决生物分子传感的关键需求。该项目利用了伊利诺伊州埃文斯顿的NU和瑞士巴塞尔的UB的各个小组中现有的基于传感器的强大研究活动。该项目的目的是开发传感器系统，是简单易用，成本效益，广泛部署，并服从大规模并行（多路复用）检测不同的生物分子物种是至关重要的许多技术？从环境监测到个人健康指标。例如，这些将包括DNA、蛋白质和病毒病原体。拟议的合作将为科学家和学生提供各自机构所不具备的设施和专门知识。国际合作还将帮助行业吸引训练有素的人员参与涉及多路复用传感器技术应用的领域。通过西北大学和巴塞尔之间的OISE国际合作计划的集体努力将为生物分子传感器的开发和应用奠定基础，该平台使用硅基检测平台，具有相当大的前景，作为一个点到护理，手持，具有成本效益和广泛部署的检测系统。

Sensing of biomolecular species with required sensitivity, specificity and engineering constraints is critical to numerous fields; ranging from environmental monitoring of toxic species to personalized health diagnostics. The diverse and multiple considerations for such a viable sensor system require interdisciplinary approach that combines the innate specificity of biological binding events, a signal transduction platform that is widely deployable and the necessary economic, ergonomic and systems-level constraints. Given such needs for diverse and multifaceted approaches, international collaborations are essential to advancing our understanding of multiplexed integrated sensor arrays for biochemical sensing. Bio-engineered sensors research requires numerous device engineering simulations, process iterations and high-level laboratory experimentation in which Northwestern (NU) and University of Basel (UB) have substantial complementary resources and expertise. This OISE collaborative project will bring together US and Swiss researchers to address the critical needs in biomolecular sensing. The project leverages strong existing cantilever-based sensors research activities in individual groups at NU in Evanston, IL and UB at Basel, Switzerland. The project aims to develop sensor systems that are simple-to-use, cost effective, widely deployable, and amenable to massively parallel (multiplexed) detection of diverse biomolecular species that are critical to many technologies ? ranging from environmental monitoring to personal health markers. These would include DNAs, proteins and viral pathogens; for example. The proposed collaboration will provide scientists and students access to facilities and expertise not available at respective individual institutions. The international collaboration will also help industries to engage highly-trained personnel in fields involving applications of multiplexed sensor technologies. The collective effort through this OISE international collaborative program between Northwestern and Basel will set the stage for biomolecular sensor development and applications using silicon-based detection platform that has considerable promise as a point-to-care, handheld, cost-effective and widely deployable detection system.