Development of a Microfabricated, Coded Aperture Mass Spectrometer

微加工编码孔径质谱仪的开发

• 批准号: 0801942
• 负责人: Jeffrey Glass
• 金额: $ 33万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0801942&HistoricalAwards=false
• 关键词: Development; Microfabricated; Coded; Aperture; Mass

Objective:The goal of this proposal is to develop a ?Coded Aperture Micro Mass Spectrometer? for ubiquitous real-time detection of environmental hazards, chemical warfare agents and biochemical markers. This will be accomplished by combining novel microfabrication technologies for ion sources and detectors with coded aperture optics and algorithms. Achievement of such a micro mass spectrometer will enable a new paradigm of sensing which simultaneously provides high sensitivity and the ability to detect a broad range of species.Intellectual Merit:The intellectual merit of the proposed work includes advancing the state of the art of coded aperture spectroscopy by confirming its value in ion-based systems and developing algorithms for magnetic sector mass spectrometry. Determining the interaction of ions with coded apertures and optimizing the algorithms for such an ion-based system also holds scientific interest for future work in computational sensing in ion based systems. Broader Impact:This research will have broad impact on future generations of ion-based instruments which desire throughput and S/N enhancements. The ion coding concepts are not limited to any one form of spectrometry and apply to all particles with mass and/or charge. The educational impact of this proposed research will also be very high for both graduate and undergraduate students. It is a truly multidisciplinary effort requiring an understanding of electrical engineering, physics, materials science and chemistry; thus, it is excellent training for future scientists. It will leverage the Pratt fellows program at Duke to bring research experiences to undergraduate students.

目标：本提案的目标是开发一种？编码孔径微质谱仪用于无处不在的环境危害、化学战剂和生化标记的实时检测。 这将通过将离子源和探测器的新型微制造技术与编码孔径光学和算法相结合来实现。这样一个微型质谱仪的实现将使一个新的范例感测，同时提供高灵敏度和检测范围广泛的species.Intellectual优点的能力：拟议的工作的智力优点包括推进编码孔径光谱的艺术状态，确认其价值在离子为基础的系统和开发算法的磁扇区质谱。 确定离子与编码孔径的相互作用并优化这种基于离子的系统的算法也对基于离子的系统中的计算感测的未来工作具有科学兴趣。 更广泛的影响：这项研究将对未来几代离子基仪器产生广泛的影响，这些仪器需要吞吐量和S/N增强。 离子编码概念不限于任何一种形式的光谱法，并且适用于具有质量和/或电荷的所有粒子。 这项拟议研究的教育影响也将是非常高的研究生和本科生。 这是一个真正的多学科的努力，需要电气工程，物理，材料科学和化学的理解;因此，它是未来科学家的优秀培训。 它将利用杜克的普拉特研究员项目为本科生带来研究经验。