Acquisition of an accurate mass quadrupole time of flight mass spectrometer

获得精确质量四极杆飞行时间质谱仪

• 批准号: 0840434
• 负责人: Jacob Petrich
• 金额: $ 38.42万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840434&HistoricalAwards=false
• 关键词: Acquisition; accurate; mass; quadrupole; time

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), Jacob W. Petrich from the Department of Chemistry at Iowa State University will acquire a cyber-enabled accurate-mass liquid chromatography, quadrupole (LCMS/MS) mass spectrometer for the Department's Mass Spectrometry Laboratory. This spectrometer possesses a solution-based sample introduction, quadrupole/ion trap precursor selection, and a time-of-flight (TOF) mass analyzer. This instrument will accommodate several forms of atmospheric pressure ionization (API) and two ionization methods: electrospray (ESI) and chemical ionization (APCI). The spectrometer will support the efforts of a diverse group of faculty and scientists involved in fundamental research to developing solutions to complex chemical problems varying from biological chemistry to catalytic processes to improve processing of soy bean oil to production of new materials to capture the energy of sunlight and light emitting diodes. Students from research groups of professors Larock, Pohl, Kraus, Verkade, Jenks and Jeffries-EL will utilize the instrument as well as other research groups from departments including chemistry, biochemistry, chemical engineering, agronomy, food science, botany, geology and entomology.LCMS/MS-TOF-mass spectrometry is an important technique for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a LCMS/MS-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项由2009年《美国复苏和再投资法案》（公共法111-5）资助。凭借化学研究仪器和设施：多用户计划（CRIF：MU）颁发的该奖项，Jacob W.来自爱荷华州州立大学化学系的Petrich将为该系的质谱实验室购买一台网络化的精确质量液相色谱四极杆（LCMS/MS）质谱仪。该光谱仪具有基于溶液的样品引入、四极杆/离子阱前体选择和飞行时间（TOF）质量分析器。 该仪器将适应几种形式的大气压电离（API）和两种电离方法：电喷雾（ESI）和化学电离（APCI）。光谱仪将支持参与基础研究的各种教师和科学家的努力，以开发解决复杂化学问题的解决方案，从生物化学到催化过程，以改善大豆油的加工，以生产新材料来捕获太阳光和发光二极管的能量。来自Larock、Pohl、Kraus、Verkade、詹克斯和Jeffries-EL教授研究小组的学生以及来自化学、生物化学、化学工程、农学、食品科学、植物学、地质学和昆虫学等部门的其他研究小组将使用该仪器。LCMS/MS-TOF-质谱是一种重要的技术，可用于获得非常大分子的精确分子量，具有极高的灵敏度。因此，LCMS/MS-TOF质谱仪的使用已成为标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。该仪器将成为教学和研究的一个组成部分。